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Information Journal Paper

Title

Serum Alpha-(1, 3)-Fucosyltransferase IV, Copper, and Zinc Levels in Patients with Colorectal Cancer and Healthy Controls

Pages

  0-0

Keywords

Alpha-(1 
3)-Fucosyltransferase IV 

Abstract

 Background: Colorectal cancer (CRC) has no significant clinical symptoms at the early stages, and the molecular differences in the serum of the patients and healthy subjects could be assessed to identify the biological markers that indicate the detection of this cancer at the levels of the biological system. Objectives: The present study aimed to assess the concentrations of the alpha-(1, 3)-fucosyltransferase IV (FUT4) enzyme and copper (Cu) and zinc (Zn) as biological elements. Methods: This case-control study was conductedon40patients with CRC, including 20menand 20women. Ametal-free sterile tube was used to collect five milliliters of venous blood. The enzyme-linked immunosorbent assay (ELISA) based on the Biotin doubleantibody sandwich technology was used to measure the human FUT4 in the sera. In addition, plasma zinc and copper values were determined using Zist Chem Diagnostics kits. Results: The mean FUT4 levels in the CRC patients was slightly higher than the control group (P = 0. 17), and the mean serum copper and zinc levels of these patients were lower than the control group with a significance difference in this regard (P < 0. 001). In addition, the AUC of FUT4, copper, and zinc was 0. 58, 0. 80, and 0. 77, respectively. Conclusions: According to the results, the altered levels of FUT4, copper, and zinc in the serum of the CRC patients compared to the healthy controls could be an indicator associated with the CRC disease course. Furthermore, the unusual changes in the FUT4, copper, and zinc levels may signify CRC development, which plays a key role in the diagnosis and monitoring of this cancer.

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    Cite

    APA: Copy

    Abbasi Natajomrani, Roya, QUJEQ, DURDI, HOSSEINI, VAHID, & HAJI HOSSEINI, REZA. (2020). Serum Alpha-(1, 3)-Fucosyltransferase IV, Copper, and Zinc Levels in Patients with Colorectal Cancer and Healthy Controls. JOURNAL OF KERMANSHAH UNIVERSITY OF MEDICAL SCIENCES (BEHBOOD), 24(4), 0-0. SID. https://sid.ir/paper/695213/en

    Vancouver: Copy

    Abbasi Natajomrani Roya, QUJEQ DURDI, HOSSEINI VAHID, HAJI HOSSEINI REZA. Serum Alpha-(1, 3)-Fucosyltransferase IV, Copper, and Zinc Levels in Patients with Colorectal Cancer and Healthy Controls. JOURNAL OF KERMANSHAH UNIVERSITY OF MEDICAL SCIENCES (BEHBOOD)[Internet]. 2020;24(4):0-0. Available from: https://sid.ir/paper/695213/en

    IEEE: Copy

    Roya Abbasi Natajomrani, DURDI QUJEQ, VAHID HOSSEINI, and REZA HAJI HOSSEINI, “Serum Alpha-(1, 3)-Fucosyltransferase IV, Copper, and Zinc Levels in Patients with Colorectal Cancer and Healthy Controls,” JOURNAL OF KERMANSHAH UNIVERSITY OF MEDICAL SCIENCES (BEHBOOD), vol. 24, no. 4, pp. 0–0, 2020, [Online]. Available: https://sid.ir/paper/695213/en

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