Serum and Urine Levels of Sarcosine in Benign Prostatic Hyperplasia and Newly Diagnosed Prostate Cancer Patients

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Yousefi Maral; QUJEQ DURDI; SHAFI HAMID; HAJIAN TILAKI KARIMOLLAH

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Journal Paper

Paper Information

Journal: Journal of Kermanshah University of Medical Sciences Year:2020 | Volume:24 | Issue:1 Page(s): 0-0

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Information Journal Paper

Title

Serum and Urine Levels of Sarcosine in Benign Prostatic Hyperplasia and Newly Diagnosed Prostate Cancer Patients

Author(s)

Yousefi Maral | QUJEQ DURDI | SHAFI HAMID | HAJIAN TILAKI KARIMOLLAH | Issue Writer Certificate

Keywords

Prostate Cancer

Prostate-specific Antigen

PSA

Sarcosine

Abstract

Background: Currently, no potent tools are available to differentiate diagnose between patients with benign prostatic hyperplasia (BPH) and newly diagnosed Prostate Cancer patients (NDPCa) based on increased serum Prostate-specific Antigen (PSA) as the value may increase in both conditions. Therefore, finding new biomarkers is considered to be a major issue in this regard. Objectives: The present study aimed to differentiate BPH and NDPCa patients and evaluate serum and urine Sarcosine levels as reliable markers. Methods: This study was conducted on 67 patients with NDPCa and BPH and healthy controls. PSA evaluation was performed on all the patients, and the serum and urine levels of Sarcosine were measured using the ELISA assay. In addition, the serum and urine Sarcosine levels were assessed using the receiver operating characteristic (ROC) curve analysis. Results: The mean serum and urine Sarcosine levels in the healthy controls were 3. 0-2. 0 and 6. 0-2. 0 ng/mL, respectively, while they were 9. 0-1. 0 and 8. 0-1. 0 ng/mL in the patients with BPH, respectively. The serum and urine Sarcosine levels in the patients with NDPCa were 21. 02-2. 0 and 15. 0-2. 0 ng/mL, respectively. Significant differences were observed in the serum and urine Sarcosine between the patients with BPH and NDPCa (P < 0. 001). In addition, the serum Sarcosine content increased in the patients with NDPCa and BPH compared to the healthy controls. The serum and urine levels of Sarcosine had the following order: healthy controls < patients with BPH

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APA: Copy

Yousefi, Maral, QUJEQ, DURDI, SHAFI, HAMID, & HAJIAN TILAKI, KARIMOLLAH. (2020). Serum and Urine Levels of Sarcosine in Benign Prostatic Hyperplasia and Newly Diagnosed Prostate Cancer Patients. JOURNAL OF KERMANSHAH UNIVERSITY OF MEDICAL SCIENCES (BEHBOOD), 24(1), 0-0. SID. https://sid.ir/paper/701339/en

Vancouver: Copy

Yousefi Maral, QUJEQ DURDI, SHAFI HAMID, HAJIAN TILAKI KARIMOLLAH. Serum and Urine Levels of Sarcosine in Benign Prostatic Hyperplasia and Newly Diagnosed Prostate Cancer Patients. JOURNAL OF KERMANSHAH UNIVERSITY OF MEDICAL SCIENCES (BEHBOOD)[Internet]. 2020;24(1):0-0. Available from: https://sid.ir/paper/701339/en

IEEE: Copy

Maral Yousefi, DURDI QUJEQ, HAMID SHAFI, and KARIMOLLAH HAJIAN TILAKI, “Serum and Urine Levels of Sarcosine in Benign Prostatic Hyperplasia and Newly Diagnosed Prostate Cancer Patients,” JOURNAL OF KERMANSHAH UNIVERSITY OF MEDICAL SCIENCES (BEHBOOD), vol. 24, no. 1, pp. 0–0, 2020, [Online]. Available: https://sid.ir/paper/701339/en

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