THE ROLES OF OPIOID RECEPTORS ON ANTICONVULSANT PROPERTIES OF HYDRO ALCOHOLIC EXTRACT OF SCROPHULARIA STRIATA BOISS IN MICE

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ALIMOHAMMADI BENYAMIN; MOSLEM ALIREZA; AZHDARI ZARMEHRI HASSAN; KAMRANIAN HOUMAN

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Journal: Journal of Sabzevar University of Medical Sciences Year:2016 | Volume:23 | Issue:2 Page(s): 204-213

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Title

THE ROLES OF OPIOID RECEPTORS ON ANTICONVULSANT PROPERTIES OF HYDRO ALCOHOLIC EXTRACT OF SCROPHULARIA STRIATA BOISS IN MICE

Author(s)

ALIMOHAMMADI BENYAMIN | MOSLEM ALIREZA | AZHDARI ZARMEHRI HASSAN | KAMRANIAN HOUMAN | Issue Writer Certificate

Keywords

NALOXONEQ2

SCROPHULARIA STRIATA BOISSQ2

ANTICONVULSANT ACTIVITYQ1

MICEQ2

Abstract

Background and Objectives: Nowadays the use of herbal plants due to their low complications attracts the mind of many scientists. The aim of this study is the assessment of the NALOXONE as an antagonist of opioids on seizure duration time induced by PTZ and determine the anticonvulsant mechanism of hydro alcoholic extract of SCROPHULARIA STRIATA BOISS.Materials & Methods: In the present study, 40 male MICE were randomly divided into five groups of eight, The control group (receiving PTZ 80 mg/kg, i.p.), Two treatment groups (Scrophularia striata 600 and 900 mg/kg, i.p.) and two experimental groups (Scrophularia striata 600 and 900 mg/kg i.p plus NALOXONE 5 mg/kg, i.p., 5 minutes before extract injection). With injection of PTZ, convulsive behaviors in MICE during 20 minutes were recorded by camera and the various stages of seizures were evaluated. Statistical data were analyzed using with the tests of one way Variance and Tukey in SPSS 16. P<0.05 was considered as the level of significance.Results: Statistical analysis showed that NALOXONE injection with extract administration have slightly and not significantly decreased the latency time to tonic and clonic seizure in comparison with the control group. Latency time to tonic-colonic has been increased in extract only group and extract associated NALOXONE group. With injection of the extract alone total seizure time has decreased but in extract associated NALOXONE group this time has increased that this increasing in dose of 600 mg/kg is significant in comparison with control group (P<0.01). Data showed that extract injection lonely and associated with NALOXONE have increased the duration time of tonic seizure, duration time of tonic-colonic with extract injection was increased but this time in NALOXONE group has been slightly decreased.Conclusion: Our study indicated that NALOXONE as an antagonist can inhibit the ANTICONVULSANT ACTIVITY of hydro alcoholic extract of SCROPHULARIA STRIATA BOISS.

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APA: Copy

ALIMOHAMMADI, BENYAMIN, MOSLEM, ALIREZA, AZHDARI ZARMEHRI, HASSAN, & KAMRANIAN, HOUMAN. (2016). THE ROLES OF OPIOID RECEPTORS ON ANTICONVULSANT PROPERTIES OF HYDRO ALCOHOLIC EXTRACT OF SCROPHULARIA STRIATA BOISS IN MICE. JOURNAL OF SABZEVAR UNIVERSITY OF MEDICAL SCIENCES, 23(2), 204-213. SID. https://sid.ir/paper/81962/en

Vancouver: Copy

ALIMOHAMMADI BENYAMIN, MOSLEM ALIREZA, AZHDARI ZARMEHRI HASSAN, KAMRANIAN HOUMAN. THE ROLES OF OPIOID RECEPTORS ON ANTICONVULSANT PROPERTIES OF HYDRO ALCOHOLIC EXTRACT OF SCROPHULARIA STRIATA BOISS IN MICE. JOURNAL OF SABZEVAR UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2016;23(2):204-213. Available from: https://sid.ir/paper/81962/en

IEEE: Copy

BENYAMIN ALIMOHAMMADI, ALIREZA MOSLEM, HASSAN AZHDARI ZARMEHRI, and HOUMAN KAMRANIAN, “THE ROLES OF OPIOID RECEPTORS ON ANTICONVULSANT PROPERTIES OF HYDRO ALCOHOLIC EXTRACT OF SCROPHULARIA STRIATA BOISS IN MICE,” JOURNAL OF SABZEVAR UNIVERSITY OF MEDICAL SCIENCES, vol. 23, no. 2, pp. 204–213, 2016, [Online]. Available: https://sid.ir/paper/81962/en

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