Acquired Hemophilia in Association With Pemphigus Vulgaris; An Uncommon Coexistence: A Case Report

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BALIGHI KAMRAN; DANESHPAZHOOH MARYAM; Mahmoudi Hamidreza; SHAKOEI SAFOURA; Aryanian Zeinab; TAVAKOLPOUR SOHEIL; AZIZPOUR ARGHAVAN

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Journal: Case Reports in Clinical Practice Year:2021 | Volume:6 | Issue:3 Page(s): 90-93

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Title

Acquired Hemophilia in Association With Pemphigus Vulgaris; An Uncommon Coexistence: A Case Report

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Keywords

emphigus

Pemphigus vulgaris

Hemophilia

Abstract

Acquired Hemophilia (AHA) is a relatively rare disease that occurs in patients with no previous family history of Hemophilia. The spontaneous development of autoantibodies (IgG1 and IgG4) against factor VIII has been reported as the most probable cause of AHA. AHA has been reported in association with other conditions, including some autoimmune bullous skin diseases, such as bullous pemphigoid, Pemphigus vulgaris, and pemphigus foliaceous. To the best of our knowledge, only 21 cases of AHA with skin autoimmune bullous diseases have been reported so far. Herein, we report a 63-year-old male with a previous history of Pemphigus vulgaris who developed large ecchymotic areas on his lower abdomen and forearms after the second infusion of rituximab. Based on coagulation factors evaluation, he was diagnosed with AHA. Treatment with factor VII led to the improvement in his coagulation status, but unfortunately, he passed away because of inferior wall myocardial infarction four days later.

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APA: Copy

BALIGHI, KAMRAN, DANESHPAZHOOH, MARYAM, Mahmoudi, Hamidreza, SHAKOEI, SAFOURA, Aryanian, Zeinab, TAVAKOLPOUR, SOHEIL, & AZIZPOUR, ARGHAVAN. (2021). Acquired Hemophilia in Association With Pemphigus Vulgaris; An Uncommon Coexistence: A Case Report. CASE REPORTS IN CLINICAL PRACTICE, 6(3), 90-93. SID. https://sid.ir/paper/695527/en

Vancouver: Copy

BALIGHI KAMRAN, DANESHPAZHOOH MARYAM, Mahmoudi Hamidreza, SHAKOEI SAFOURA, Aryanian Zeinab, TAVAKOLPOUR SOHEIL, AZIZPOUR ARGHAVAN. Acquired Hemophilia in Association With Pemphigus Vulgaris; An Uncommon Coexistence: A Case Report. CASE REPORTS IN CLINICAL PRACTICE[Internet]. 2021;6(3):90-93. Available from: https://sid.ir/paper/695527/en

IEEE: Copy

KAMRAN BALIGHI, MARYAM DANESHPAZHOOH, Hamidreza Mahmoudi, SAFOURA SHAKOEI, Zeinab Aryanian, SOHEIL TAVAKOLPOUR, and ARGHAVAN AZIZPOUR, “Acquired Hemophilia in Association With Pemphigus Vulgaris; An Uncommon Coexistence: A Case Report,” CASE REPORTS IN CLINICAL PRACTICE, vol. 6, no. 3, pp. 90–93, 2021, [Online]. Available: https://sid.ir/paper/695527/en

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