EFFECT OF THYMOL ON SERUM ANTIOXIDANT CAPACITY OF RATS FOLLOWING MYOCARDIAL HYPERTROPHY

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Jamhiri Mohabbat; HAFIZIBARJIN ZEINAB; GHOBADI MOJTABA; MORADI ALI; SAFARI FATEMEH

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Journal: Journal of Arak University Medical Sciences Year:2017 | Volume:20 | Issue:4 (121) Page(s): 10-19

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Title

EFFECT OF THYMOL ON SERUM ANTIOXIDANT CAPACITY OF RATS FOLLOWING MYOCARDIAL HYPERTROPHY

Author(s)

Keywords

CATALASEQ2

MALONDIALDEHYDEQ1

DPPHQ2

MYOCARDIAL HYPERTROPHYQ2

OXIDATIVE STRESSQ1

THYMOLQ1

Abstract

Background: OXIDATIVE STRESS plays an important role in the pathogenesis of hypertensioninduced cardiac hypertrophy. Plants are a rich source of antioxidant compounds. THYMOL is a natural monoterpen phenol which is plentiful in some plants and shows many biological effects. The aim of the present study was to assess the effects of THYMOL on activity of antioxidant enzyme CATALASE, MALONDIALDEHYDE (MDA) level and the activity of the inhibition of free radical DPPH (2, 2-Diphenyl-1-picryl-hydrazyl), following left ventricular hypertrophy in rats.Materials and Methods: In this experimental study, rats were divided into hypertrophied group without any treatment (H group) and rats pretreated with 25 and 50 mg/kg/day of THYMOL (Thy25+H and Thy50+H groups, respectively). Intact animals were served as control (Ctl). Animal model of left ventricular hypertrophy was induced by abdominal aortic banding. Serum CATALASE (CAT) activity, MALONDIALDEHYDE (MDA) level and the activity of inhibition of free radicals DPPH were determined by the biochemical methods.Results: In Thy25+H and Thy50+H groups, the CAT activity was increased significantly in serum (p<0.01, vs. Ctl). Also, serum level of MDA was decreased significantly compared to the group H in Thy25+H and Thy50+H groups (p<0.05 and p<0.001, respectively). The effect of inhibiting DPPH free radicals was increased significantly in Thy25+H and Thy50+H groups compared to the group H (p<0.001 and p<0.05, respectively).Conclusion: The findings of this study suggest that THYMOL as an antioxidant causes cardioprotective effects and as well as prevents left ventricular hypertrophy via augmentation of serum antioxidant capacity.

Cites

References

THE EFFECT OF RESVERATROL ON ANGIOTENSIN II LEVELS AND THE RATE OF TRANSCRIPTION OF ITS RECEPTORS IN THE RAT CARDIAC HYPERTROPHY MODEL

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APA: Copy

Jamhiri, Mohabbat, HAFIZIBARJIN, ZEINAB, GHOBADI, MOJTABA, MORADI, ALI, & SAFARI, FATEMEH. (2017). EFFECT OF THYMOL ON SERUM ANTIOXIDANT CAPACITY OF RATS FOLLOWING MYOCARDIAL HYPERTROPHY. ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ), 20(4 (121)), 10-19. SID. https://sid.ir/paper/69556/en

Vancouver: Copy

Jamhiri Mohabbat, HAFIZIBARJIN ZEINAB, GHOBADI MOJTABA, MORADI ALI, SAFARI FATEMEH. EFFECT OF THYMOL ON SERUM ANTIOXIDANT CAPACITY OF RATS FOLLOWING MYOCARDIAL HYPERTROPHY. ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ)[Internet]. 2017;20(4 (121)):10-19. Available from: https://sid.ir/paper/69556/en

IEEE: Copy

Mohabbat Jamhiri, ZEINAB HAFIZIBARJIN, MOJTABA GHOBADI, ALI MORADI, and FATEMEH SAFARI, “EFFECT OF THYMOL ON SERUM ANTIOXIDANT CAPACITY OF RATS FOLLOWING MYOCARDIAL HYPERTROPHY,” ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ), vol. 20, no. 4 (121), pp. 10–19, 2017, [Online]. Available: https://sid.ir/paper/69556/en

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