MYOCARDIAL IRON LOAD MEASURED BY CARDIAC MAGNETIC RESONANCE IMAGING TO EVALUATE CARDIAC SYSTOLIC FUNCTION IN THALASSEMIA

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

KAHNOOJI MASOUMEH; RASHIDINEJAD HAMID REZA; YAZDANPANAH MOHAMMAD SHAHRAM; AZDAKI NAHID; NAGHIBZADEH TAHAMI AHMAD

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: ARYA Atherosclerosis Year:2016 | Volume:12 | Issue:5 Page(s): 0-0

Download Full-Text

View:

206

Download:

122

Cites:

Information Journal Paper

Title

MYOCARDIAL IRON LOAD MEASURED BY CARDIAC MAGNETIC RESONANCE IMAGING TO EVALUATE CARDIAC SYSTOLIC FUNCTION IN THALASSEMIA

Author(s)

Keywords

THALASSEMIA

IRON OVERLOAD

MAGNETIC RESONANCE IMAGING

FERRITIN

ACCURACY

Abstract

BACKGROUND: The assessment of cardiac IRON OVERLOAD in THALASSEMIA major has been considered as an important predictive factor of heart injury. The MAGNETIC RESONANCE IMAGING (MRI) -derived relaxation time parameter (T2*) varies inversely with iron level, and elevated myocardial iron levels by T2* are associated with depressed left ventricular (LV) ejection fraction (EF). We compared echocardiographic (ECHO) indices of systolic function to myocardial T2* in these patients.METHODS: A cross-sectional database review identified 200 consecutive patients with THALASSEMIA who underwent both ECHO and MRI T2* assessment.RESULTS: There was a negative correlation between T2* measurement and ECHO EF (r=−0.389, P<0.001). Using a cutoff value of 50% for differentiating LV normal and abnormal function by ECHO, T2* MRI had a sensitivity of 57.1%, a specificity of 89.9%, and an ACCURACY of 86.5% for predicting LV dysfunction. Receiver operating characteristic analysis showed that cardiac iron measurement had an acceptable value for discriminating normal and abnormal LV function (area under the curve=0.769, 95% confidence interval: 0.653-0.885). With respect to the relationship between serum FERRITIN level and cardiac iron value, the level of serum FERRITIN was positively correlated with the level of cardiac iron load (r=0.257, P<0.001).CONCLUSION: Myocardial iron load assessed by MRI T2* is associated with deterioration of the LV function assessed by ECHO with a high specificity and moderate sensitivity. It is important to identify the thalassemic patients with a risk of IRON OVERLOADed cardiomyopathy and heart failure.

Cites

No record.

References

No record.

Cite

APA: Copy

KAHNOOJI, MASOUMEH, RASHIDINEJAD, HAMID REZA, YAZDANPANAH, MOHAMMAD SHAHRAM, AZDAKI, NAHID, & NAGHIBZADEH TAHAMI, AHMAD. (2016). MYOCARDIAL IRON LOAD MEASURED BY CARDIAC MAGNETIC RESONANCE IMAGING TO EVALUATE CARDIAC SYSTOLIC FUNCTION IN THALASSEMIA. ARYA ATHEROSCLEROSIS, 12(5), 0-0. SID. https://sid.ir/paper/695620/en

Vancouver: Copy

KAHNOOJI MASOUMEH, RASHIDINEJAD HAMID REZA, YAZDANPANAH MOHAMMAD SHAHRAM, AZDAKI NAHID, NAGHIBZADEH TAHAMI AHMAD. MYOCARDIAL IRON LOAD MEASURED BY CARDIAC MAGNETIC RESONANCE IMAGING TO EVALUATE CARDIAC SYSTOLIC FUNCTION IN THALASSEMIA. ARYA ATHEROSCLEROSIS[Internet]. 2016;12(5):0-0. Available from: https://sid.ir/paper/695620/en

IEEE: Copy

MASOUMEH KAHNOOJI, HAMID REZA RASHIDINEJAD, MOHAMMAD SHAHRAM YAZDANPANAH, NAHID AZDAKI, and AHMAD NAGHIBZADEH TAHAMI, “MYOCARDIAL IRON LOAD MEASURED BY CARDIAC MAGNETIC RESONANCE IMAGING TO EVALUATE CARDIAC SYSTOLIC FUNCTION IN THALASSEMIA,” ARYA ATHEROSCLEROSIS, vol. 12, no. 5, pp. 0–0, 2016, [Online]. Available: https://sid.ir/paper/695620/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops