INVESTIGATION OF PSEN1, 2 HOT SPOTS IN IRANIAN EARLY-ONSET ALZHEIMER'S DISEASE PATIENTS

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

AKBARI LEILA

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Zahedan Journal of Research in Medical Sciences Year:2015 | Volume:17 | Issue:2 Page(s): 0-0

Download Full-Text

View:

260

Download:

Cites:

Information Journal Paper

Title

INVESTIGATION OF PSEN1, 2 HOT SPOTS IN IRANIAN EARLY-ONSET ALZHEIMER'S DISEASE PATIENTS

Author(s)

AKBARI LEILA | Issue Writer Certificate

Keywords

ALZHEIMER DISEASE

PSEN1 GENE

PSEN2 GENE

MUTATION

IRAN

Abstract

Background: Alzheimer's disease is a progressive, neurodegenerative disease with bothgenetic and non genetic causes. Familial Alzheimer's disease can be caused by MUTATIONs inthe amyloid precursor protein, presenilin 1 and presenilin 2. Early-onset familialAlzheimer's disease (autosomal dominantly inherited) accounts for a small fraction (2-3%)of Alzheimer's disease cases. The aim of this study was investigation of exons 5, 7 inPSEN1 and exons 5, 6 in PSEN2 GENEs in IRANian patients with early onset Alzheimerdisease. These exons were hot spots in different country.Materials and Methods: In this experimental study 24 patients with early onset Alzheimerdisease and 48 healthy subjects as control group were included in this study. After DNAsextraction from whole blood, PCR-sequencing was used to amplify and analyze 4 exons.Results: Two known MUTATIONs (Glu 120 Lys in exon 3 of two patients and Arg 62 His inexon 5 of one patient) were found.Conclusion: According to the above findings, these exons were not hot spot in IRAN.

Cites

No record.

References

No record.

Cite

APA: Copy

AKBARI, LEILA. (2015). INVESTIGATION OF PSEN1, 2 HOT SPOTS IN IRANIAN EARLY-ONSET ALZHEIMER'S DISEASE PATIENTS. ZAHEDAN JOURNAL OF RESEARCH IN MEDICAL SCIENCES (TABIB-E-SHARGH), 17(2), 0-0. SID. https://sid.ir/paper/695766/en

Vancouver: Copy

AKBARI LEILA. INVESTIGATION OF PSEN1, 2 HOT SPOTS IN IRANIAN EARLY-ONSET ALZHEIMER'S DISEASE PATIENTS. ZAHEDAN JOURNAL OF RESEARCH IN MEDICAL SCIENCES (TABIB-E-SHARGH)[Internet]. 2015;17(2):0-0. Available from: https://sid.ir/paper/695766/en

IEEE: Copy

LEILA AKBARI, “INVESTIGATION OF PSEN1, 2 HOT SPOTS IN IRANIAN EARLY-ONSET ALZHEIMER'S DISEASE PATIENTS,” ZAHEDAN JOURNAL OF RESEARCH IN MEDICAL SCIENCES (TABIB-E-SHARGH), vol. 17, no. 2, pp. 0–0, 2015, [Online]. Available: https://sid.ir/paper/695766/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops