THE ROLE OF INDUCIBLE NITRIC OXIDE SYNTHASE (INOS) IN ISCHEMIA/REPERFUSION-INDUCED ACUTE RENAL FAILURE IN ANAESTHETIZED RATS

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GHOLAMPOUR F.; SHID MOUSAVI SEYED MOSTAFA; OUJI S.M.; HAJIZADEH S.

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Journal: ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ) Year:2010 | Volume:12 | Issue:4 (49) Page(s): 51-60

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Title

THE ROLE OF INDUCIBLE NITRIC OXIDE SYNTHASE (INOS) IN ISCHEMIA/REPERFUSION-INDUCED ACUTE RENAL FAILURE IN ANAESTHETIZED RATS

Author(s)

GHOLAMPOUR F. | SHID MOUSAVI SEYED MOSTAFA | OUJI S.M. | HAJIZADEH S. | Issue Writer Certificate

Keywords

GLOMERULAR FILTERATIONQ3

INOS ENZYMEQ3

ISCHEMIAQ3

L-NILQ3

REPERFUSIONQ3

Abstract

Background: ISCHEMIA/reperfusion-induced acute renal failure causes excretory functional disorders of nephrones. ISCHEMIA/reperfusion injury increases INOS expression in the renal tissue. Inhibition of INOS expression and its activity can ameliorate ISCHEMIA/reperfusion-induced renal injury. The aim of this study was to determine the role of INOS on progression of renal functional disturbances over the immediate post-ischemic REPERFUSION period.Materials and Methods: In this experimental study, renal hemodynamic and excretory functions were evaluated in male Sprague-Dawley rats. First, a 30-min control clearance period was taken. Then following bilateral renal artery clamping for 30 minutes, four consecutive 30-min clearance periods were taken during REPERFUSION, while saline or L-NIL as a selective INOS inhibitor was infused. In plasma and urine samples, Cr and sodium concentration levels were measured. Results: Renal ISCHEMIA for 30 minutes decreased glomerular filtration rate and urine osmolality during REPERFUSION and increased urine flow and sodium excretion. L-NIL did not change the glomerular filtration rate and urine osmolality prior to ISCHEMIA but it improved them during REPERFUSION and there were progressive increases in urine flow. Additionally, L-NIL lowered ISCHEMIA-induced rises in sodium excretion. Conclusion: INOS had a considerable role in the development of disorders in hemodynamic and excretory renal functions during early hours after ISCHEMIA.

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APA: Copy

GHOLAMPOUR, F., SHID MOUSAVI, SEYED MOSTAFA, OUJI, S.M., & HAJIZADEH, S.. (2010). THE ROLE OF INDUCIBLE NITRIC OXIDE SYNTHASE (INOS) IN ISCHEMIA/REPERFUSION-INDUCED ACUTE RENAL FAILURE IN ANAESTHETIZED RATS. ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ), 12(4 (49)), 51-60. SID. https://sid.ir/paper/69604/en

Vancouver: Copy

GHOLAMPOUR F., SHID MOUSAVI SEYED MOSTAFA, OUJI S.M., HAJIZADEH S.. THE ROLE OF INDUCIBLE NITRIC OXIDE SYNTHASE (INOS) IN ISCHEMIA/REPERFUSION-INDUCED ACUTE RENAL FAILURE IN ANAESTHETIZED RATS. ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ)[Internet]. 2010;12(4 (49)):51-60. Available from: https://sid.ir/paper/69604/en

IEEE: Copy

F. GHOLAMPOUR, SEYED MOSTAFA SHID MOUSAVI, S.M. OUJI, and S. HAJIZADEH, “THE ROLE OF INDUCIBLE NITRIC OXIDE SYNTHASE (INOS) IN ISCHEMIA/REPERFUSION-INDUCED ACUTE RENAL FAILURE IN ANAESTHETIZED RATS,” ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ), vol. 12, no. 4 (49), pp. 51–60, 2010, [Online]. Available: https://sid.ir/paper/69604/en

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