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Information Journal Paper

Title

INHIBITORY EFFECT OF CAPPARIS SPINOSA EXTRACT ON PANCREATIC ALPHA-AMYLASE ACTIVITY

Pages

  0-0

Abstract

 Background: DIABETES MELLITUS is a metabolic disorder characterized by high blood glucose level caused due to deficiency of insulin secretion or insulin function. The inhibition of carbohydrate hydrolyzing enzymes such as a-amylase can be an important strategy for decrease postprandial blood glucose level in patients with type II diabetes. Plants contains different chemical constituents with potential for inhibition of a-amylase and hence maybe used as therapeutic.Objectives: The aim of the present study is to investigate the effect of the ethanolic extract of CAPPARIS SPINOSA on pancreatic a-amylase activities to find out the relevance of the plant in controlling blood sugar.Materials and Methods: In this experimental study, root and leaves of C. spinosa were tested for a-amylase inhibition. Different concentrations (1.56, 3.12, 6.25, 12.5 and 25 mg/mL) of extracts were incubated with enzyme substrate solution and the spectrometric method used for measure enzyme activity. Also acarbose was used as the standard inhibitor.Results: Both rootandleaves extractsshowedinhibition of a-amylase (root=97.31% andleaves=98.92%). Therootandleaves extracts of C. spinosa exhibited appreciable a-amylase inhibitory activity with an IC50 values 5.93 mg/mL and 3.89 mg/mL respectively, when compared with acarbose (IC50 value 0.038 mg/mL).Conclusions: This study supports that root and leaves extracts of C. spinosa exhibit considerable a-amylase inhibitory activities. These results could be useful for developing functional foods by combination of plant-based foods for treatment of DIABETES MELLITUS.

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    APA: Copy

    SELFAYAN, MOSTAFA, & NAMJOOYAN, FOROOGH. (2016). INHIBITORY EFFECT OF CAPPARIS SPINOSA EXTRACT ON PANCREATIC ALPHA-AMYLASE ACTIVITY. ZAHEDAN JOURNAL OF RESEARCH IN MEDICAL SCIENCES (TABIB-E-SHARGH), 18(4), 0-0. SID. https://sid.ir/paper/696203/en

    Vancouver: Copy

    SELFAYAN MOSTAFA, NAMJOOYAN FOROOGH. INHIBITORY EFFECT OF CAPPARIS SPINOSA EXTRACT ON PANCREATIC ALPHA-AMYLASE ACTIVITY. ZAHEDAN JOURNAL OF RESEARCH IN MEDICAL SCIENCES (TABIB-E-SHARGH)[Internet]. 2016;18(4):0-0. Available from: https://sid.ir/paper/696203/en

    IEEE: Copy

    MOSTAFA SELFAYAN, and FOROOGH NAMJOOYAN, “INHIBITORY EFFECT OF CAPPARIS SPINOSA EXTRACT ON PANCREATIC ALPHA-AMYLASE ACTIVITY,” ZAHEDAN JOURNAL OF RESEARCH IN MEDICAL SCIENCES (TABIB-E-SHARGH), vol. 18, no. 4, pp. 0–0, 2016, [Online]. Available: https://sid.ir/paper/696203/en

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