The Regulation of the Concentrations of Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-Alpha and Sirtuin 1 Protein in the Soleus Muscle by Aerobic Exercise Training in Obese Wistar Rats

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HEJAZI KEYVAN; ATTARZADEH HOSSEINI SEYYED REZA; FATHI MEHRDAD; MOSAFERI ZIAALDINI MOHAMMAD

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Journal: Journal of Kermanshah University of Medical Sciences Year:2020 | Volume:24 | Issue:3 Page(s): 0-0

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Title

The Regulation of the Concentrations of Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-Alpha and Sirtuin 1 Protein in the Soleus Muscle by Aerobic Exercise Training in Obese Wistar Rats

Author(s)

HEJAZI KEYVAN | ATTARZADEH HOSSEINI SEYYED REZA | FATHI MEHRDAD | MOSAFERI ZIAALDINI MOHAMMAD | Issue Writer Certificate

Keywords

Aerobic Training

PGC-1a

SIRT1

Obese Rat

Abstract

Background: Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1a) and Sirtuin 1 (SIRT1) are significant indicators of obesity and other metabolic disorders. Objectives: The present study aimed to investigate the regulation of the concentrations of PGC-1a and SIRT1 protein in the soleus muscle by aerobic exercise training in obese Wistar rats. Methods: This study was conducted on 24 obese male rats, which were randomly categorized into three groups of control, mediumintensity training (28 m/min), and high-intensity training (34 m/min) after obesity induction through a high-fat diet. A series of Aerobic Trainings in five sessions of 60-minute Aerobic Training per week was performed for eight weeks. Data analysis was performed using one-way ANOVA to examine the mean differences between the groups. In addition, Tukey’ s post-hoc test was used for the paired comparisons of the groups. Results: Significant differences were observed in the concentrations of the PGC-1a (P < 0. 001) and SIRT1 proteins between the study groups (P < 0. 001). Tukey’ s post-hoc test revealed a significant difference between the moderate-intensity aerobic exercise and control groups (P < 0. 01) regarding their mean concentration of the PGC-1a protein. However, the high-and moderate-intensity groups showed no difference in this regard (P< 0. 028). Moreover, there was a significant difference in the concentration of the SIRT1 protein between the moderate-intensity aerobic exercise and control groups (P < 0. 02), and the high-intensity training and control groups (P < 0. 005). Conclusions: According to the results, aerobic exercise training could activate SIRT1 and PGC-1a andmight enhance mitochondrial biogenesis in the subcutaneous fat. Therefore, Aerobic Training is recommended as a therapeutic approach to obesity and several other metabolic diseases.

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APA: Copy

HEJAZI, KEYVAN, ATTARZADEH HOSSEINI, SEYYED REZA, FATHI, MEHRDAD, & MOSAFERI ZIAALDINI, MOHAMMAD. (2020). The Regulation of the Concentrations of Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-Alpha and Sirtuin 1 Protein in the Soleus Muscle by Aerobic Exercise Training in Obese Wistar Rats. JOURNAL OF KERMANSHAH UNIVERSITY OF MEDICAL SCIENCES (BEHBOOD), 24(3), 0-0. SID. https://sid.ir/paper/696340/en

Vancouver: Copy

HEJAZI KEYVAN, ATTARZADEH HOSSEINI SEYYED REZA, FATHI MEHRDAD, MOSAFERI ZIAALDINI MOHAMMAD. The Regulation of the Concentrations of Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-Alpha and Sirtuin 1 Protein in the Soleus Muscle by Aerobic Exercise Training in Obese Wistar Rats. JOURNAL OF KERMANSHAH UNIVERSITY OF MEDICAL SCIENCES (BEHBOOD)[Internet]. 2020;24(3):0-0. Available from: https://sid.ir/paper/696340/en

IEEE: Copy

KEYVAN HEJAZI, SEYYED REZA ATTARZADEH HOSSEINI, MEHRDAD FATHI, and MOHAMMAD MOSAFERI ZIAALDINI, “The Regulation of the Concentrations of Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-Alpha and Sirtuin 1 Protein in the Soleus Muscle by Aerobic Exercise Training in Obese Wistar Rats,” JOURNAL OF KERMANSHAH UNIVERSITY OF MEDICAL SCIENCES (BEHBOOD), vol. 24, no. 3, pp. 0–0, 2020, [Online]. Available: https://sid.ir/paper/696340/en

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