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Information Journal Paper

Title

Effect of Vigorous Aerobic Exercise on Serum Levels of SIRT1, FGF21 and Fetuin A in Women with Type II Diabetes

Pages

  1-6

Abstract

 Background and Objectives: Sirtuin (SIRT), Fibroblast Growth Factor21 (FGF21) and Fetuin A are proteins that cause a wide range of metabolic disorders such as type 2 diabetes mellitus (T2DM). On the other hand, regular physical activity is known to play a key role in prevention and management of T2DM. Thus, this study investigated the effect of vigorous aerobic Exercise on serum levels of metabolic parameters including SIRT1, FGF21 and Fetuin A in women with T2DM. Methods: The study was performed on 28 randomly selected women with T2DM who were divided into an Exercise group and a control group. The training intervention consisted eight weeks of vigorous aerobic Exercise (three times a week at 70-80% of maximum heart rate). The serum levels of SIRT1, FGF21 and Fetuin A were evaluated before the first session and 48 hours after the last session. Paired sample t-test and independent t-test were used to analyze within and between group differences, respectively. All statistical analyses were performed in SPSS (version 19) at significance of 0. 05. Results: The eight-week aerobic training caused a significant reduction in body weight, body mass index, insulin resistance, low-density lipoprotein, fasting blood sugar, triglycerides and Fetuin A of women with T2DM. In addition, it caused a significant increase in SIRT1 and FGF21 levels. There was no significant difference in the level of high-density lipoprotein and cholesterol between the two groups. Conclusion: As a non-pharmacological therapy, regular aerobic Exercise might improve the metabolic parameters, SIRT1, FGF21, and Fetuin A in women with T2DM.

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References

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APA: Copy

VIZVARI, EXIR, FARZANEGI, PARVIN, & Abbas Zade Sourati, Hajar. (2018). Effect of Vigorous Aerobic Exercise on Serum Levels of SIRT1, FGF21 and Fetuin A in Women with Type II Diabetes. MEDICAL LABORATORY JOURNAL, 12(2), 1-6. SID. https://sid.ir/paper/718223/en

Vancouver: Copy

VIZVARI EXIR, FARZANEGI PARVIN, Abbas Zade Sourati Hajar. Effect of Vigorous Aerobic Exercise on Serum Levels of SIRT1, FGF21 and Fetuin A in Women with Type II Diabetes. MEDICAL LABORATORY JOURNAL[Internet]. 2018;12(2):1-6. Available from: https://sid.ir/paper/718223/en

IEEE: Copy

EXIR VIZVARI, PARVIN FARZANEGI, and Hajar Abbas Zade Sourati, “Effect of Vigorous Aerobic Exercise on Serum Levels of SIRT1, FGF21 and Fetuin A in Women with Type II Diabetes,” MEDICAL LABORATORY JOURNAL, vol. 12, no. 2, pp. 1–6, 2018, [Online]. Available: https://sid.ir/paper/718223/en

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