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Title

The Effect of High Intensity Interval Training (HIIT) and Crocin Consumption on Some Doxorubicin-Induced Apoptotic Indices in the Soleus Muscle Tissue of Rats

Pages

  0-0

Abstract

 Background: Apoptosis is one of the main means to remove undesirable cells that occurs in the eucaryotic and even procaryotic organisms. Objectives: This study aimed to examine the effect of 8 weeks of high-intensity interval Training (HIIT) and Crocin consumption on apoptotic factors in the soleus muscle of male rats exposed to Doxorubicin. Methods: sixty male rats were selected and divided into five groups: 1) doxorbicin-control, 2) Training, 3) Crocin, 4) Training + Crocin, and 5) healthy control. Groups 1 to 4 received 2mg/ kg Doxorubicin intraperitoneally; Groups 3 and 4 received daily 10mg/ kg Crocin, and groups 2 and 5 received HIIT including high-intensity interval repetitions (80 to 90% of maximum speed) and low-intensity interval repetitions (30 to 40% of maximum speed) at two-minute alternations for eight weeks and for five days each week. Results: Doxorubicin had a significant effect on increasing Bax and caspase-3 and decreasing Bcl-2 (P 0. 05). However, Training had a significant effect on reducing Bax and increasing Bcl-2 (P 0. 05). Crocin consumption had a significant effect on decreasing Bax and caspase-3 and increasing Bcl-2 (P  0. 05). In addition, Training and Crocin consumption had interactive effects on decreasing Bax and increasing Bcl-2 (P 0. 05). Conclusions: It appears that the combination of HIIT with Crocin extract can be used to increase the expression of the Bcl-2 protein gene as an anti-apoptotic factor and decrease the expression of Bax gene as a stimulating factor in the soleus muscle of male rats exposed to Doxorubicin.

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    APA: Copy

    Eydivandi, Kavous, AZARBAYJANI, MOHAMMAD ALI, & FARZANEGI, PARVIN. (2020). The Effect of High Intensity Interval Training (HIIT) and Crocin Consumption on Some Doxorubicin-Induced Apoptotic Indices in the Soleus Muscle Tissue of Rats. GENE, CELL AND TISSUE, 7(4), 0-0. SID. https://sid.ir/paper/696500/en

    Vancouver: Copy

    Eydivandi Kavous, AZARBAYJANI MOHAMMAD ALI, FARZANEGI PARVIN. The Effect of High Intensity Interval Training (HIIT) and Crocin Consumption on Some Doxorubicin-Induced Apoptotic Indices in the Soleus Muscle Tissue of Rats. GENE, CELL AND TISSUE[Internet]. 2020;7(4):0-0. Available from: https://sid.ir/paper/696500/en

    IEEE: Copy

    Kavous Eydivandi, MOHAMMAD ALI AZARBAYJANI, and PARVIN FARZANEGI, “The Effect of High Intensity Interval Training (HIIT) and Crocin Consumption on Some Doxorubicin-Induced Apoptotic Indices in the Soleus Muscle Tissue of Rats,” GENE, CELL AND TISSUE, vol. 7, no. 4, pp. 0–0, 2020, [Online]. Available: https://sid.ir/paper/696500/en

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