EFFECT OF ALLIUM SATIVUM EXTRACT ON ACID AND PEPSIN SECRETION IN BASAL CONDITION AND STIMULATED WITH PENTAGASTRIN IN RAT

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SHAHRANI M.; NABAVIZADEH F.; RAFIEIAN MAHMOUD; SHIRZAD H.A.; HASHEMZADEH CHALESHTORI M.; YOUSEFI HOSSEIN; KHADIVI R.; AMINI S.A.A.; KHALILI BAHMAN; RAHIMIAN GH.A.; MORADI M.T.; ETEMADIFAR SH.

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Journal: Journal of Arak University Medical Sciences Year:2007 | Volume:10 | Issue:3 (40) Page(s): 48-57

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Title

EFFECT OF ALLIUM SATIVUM EXTRACT ON ACID AND PEPSIN SECRETION IN BASAL CONDITION AND STIMULATED WITH PENTAGASTRIN IN RAT

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Keywords

ALLIUM SATIVUM EXTRACTQ3

GASTRIC ACIDQ3

GASTRIC PEPSINQ3

PENTAGASTRINQ3

Abstract

Introduction: Allium Sativum (garlic) is used widely in the world and especially in Iran. This plant is used in cooking food as an odorant. In Iran it is believed that it is useful for gastrointestinal disorders. So in this study the effect of ALLIUM SATIVUM EXTRACT on acid and pepsin secretion in rat is investigated. Materials and Methods: This experimental study is performed on two groups of rats (12 in each group: control group and allium sativum group). After anesthesia with nesdonal (50 mg/kg, ip), rats had gone under surgical tracheotomy, laparatomy and gasterodeodenostomy. In garlic group ALLIUM SATIVUM EXTRACT (100 mg/kg) was introduced into the stomach by gasterodeodenostomy canula. In order to stimulation of acid and pepsin secretion, PENTAGASTRIN was used (25 mcg/kg, ip). Stomach secretion was washed out and acid was measured using titerimetery and pepsin using Anson method. Data was analyzed using T test. Results: Allium Sativum caused a meaningful increase in acid and pepsin secretion in garlic group comparing to control group (p<0.001). PENTAGASTRIN also increased acid and pepsin secretion in control group (p<0.001).Conclusion: Using garlic in nutritional regimen causes an increase in acid and pepsin secretion in those using this plant.

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APA: Copy

SHAHRANI, M., NABAVIZADEH, F., RAFIEIAN, MAHMOUD, SHIRZAD, H.A., HASHEMZADEH CHALESHTORI, M., YOUSEFI, HOSSEIN, KHADIVI, R., AMINI, S.A.A., KHALILI, BAHMAN, RAHIMIAN, GH.A., MORADI, M.T., & ETEMADIFAR, SH.. (2007). EFFECT OF ALLIUM SATIVUM EXTRACT ON ACID AND PEPSIN SECRETION IN BASAL CONDITION AND STIMULATED WITH PENTAGASTRIN IN RAT. ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ), 10(3 (40)), 48-57. SID. https://sid.ir/paper/69660/en

Vancouver: Copy

SHAHRANI M., NABAVIZADEH F., RAFIEIAN MAHMOUD, SHIRZAD H.A., HASHEMZADEH CHALESHTORI M., YOUSEFI HOSSEIN, KHADIVI R., AMINI S.A.A., KHALILI BAHMAN, RAHIMIAN GH.A., MORADI M.T., ETEMADIFAR SH.. EFFECT OF ALLIUM SATIVUM EXTRACT ON ACID AND PEPSIN SECRETION IN BASAL CONDITION AND STIMULATED WITH PENTAGASTRIN IN RAT. ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ)[Internet]. 2007;10(3 (40)):48-57. Available from: https://sid.ir/paper/69660/en

IEEE: Copy

M. SHAHRANI, F. NABAVIZADEH, MAHMOUD RAFIEIAN, H.A. SHIRZAD, M. HASHEMZADEH CHALESHTORI, HOSSEIN YOUSEFI, R. KHADIVI, S.A.A. AMINI, BAHMAN KHALILI, GH.A. RAHIMIAN, M.T. MORADI, and SH. ETEMADIFAR, “EFFECT OF ALLIUM SATIVUM EXTRACT ON ACID AND PEPSIN SECRETION IN BASAL CONDITION AND STIMULATED WITH PENTAGASTRIN IN RAT,” ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ), vol. 10, no. 3 (40), pp. 48–57, 2007, [Online]. Available: https://sid.ir/paper/69660/en

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