The Effect of Aerobic Training and Ozone Therapy on the Levels of MFN1 and DRP1 Gene Expression in the Heart Tissue of Rats with Osteoarthritis

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Zandi Atosa; AZARBAYJANI MOHAMMAD ALI; PEERI MAGHSOUD; HOSSEINI SEYED ALI

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Journal: Gene, Cell and Tissue Year:2020 | Volume:7 | Issue:4 Page(s): 0-0

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Title

The Effect of Aerobic Training and Ozone Therapy on the Levels of MFN1 and DRP1 Gene Expression in the Heart Tissue of Rats with Osteoarthritis

Author(s)

Zandi Atosa | AZARBAYJANI MOHAMMAD ALI | PEERI MAGHSOUD | HOSSEINI SEYED ALI | Issue Writer Certificate

Keywords

Training

Ozone

Osteoarthritis

MFN1

DRP1 1.Background

Abstract

Background: People with Osteoarthritis are at increased risk of cardiovascular diseases. However, regular exercise and Ozone therapy can prevent such diseases. Objectives: The current study aimed to investigate the effect of aerobic Training and Ozone therapy on the gene expression of MFN1 and DRP1 in the heart tissue of rats with Osteoarthritis. Methods: In this experimental study, 24 rats with Osteoarthritis were randomly divided into four groups of six rats, including (1) Osteoarthritis control, (2) Training, (3) Ozone, and (4) Training + Ozone. Also, to investigate the effects of Osteoarthritis on intended variables, 6 healthy rats were selected as the healthy control group. Then, for the next eight weeks, rats in the aerobic Training groups were planned to run on the treadmill five sessions per week for 30-50 minutes, and those in the Ozone groups received 20 g/mL Ozone once per week for three weeks, 21 days after induction of Osteoarthritis. Gene expression levels of MFN1 and DRP1 were measured in the heart tissue. The Shapiro-Wilk, one-way ANOVA, and Tukey’ s post-hoc tests were used to analyze the data (P 0. 05). Results: Induction of Osteoarthritis was associated with increases in MFN1 (P = 0. 001) and DRP1 (P = 0. 001). However, in the Training, Ozone therapy, and Training + Ozone therapy groups, Osteoarthritis decreased the DRP1 (P = 0. 001); Training (P = 0. 02), Ozone therapy (P = 0. 002), and Training + Ozone therapy (P = 0. 001) decreased the MFN1; Also, reduction in MFN1 and DRP1 was greater in the Training + Ozone therapy group than the sole Training group (P = 0. 001). Conclusions: Although eight weeks of Training and Ozone therapy improved the levels of MFN1 and DRP1 gene expression in the heart tissue of rats with Osteoarthritis, simultaneous use of Training with Ozone therapy showed more favorable effects on the improvement of MFN1 and DRP1 gene expression levels than sole Training or Ozone therapy alone.

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APA: Copy

Zandi, Atosa, AZARBAYJANI, MOHAMMAD ALI, PEERI, MAGHSOUD, & HOSSEINI, SEYED ALI. (2020). The Effect of Aerobic Training and Ozone Therapy on the Levels of MFN1 and DRP1 Gene Expression in the Heart Tissue of Rats with Osteoarthritis. GENE, CELL AND TISSUE, 7(4), 0-0. SID. https://sid.ir/paper/696673/en

Vancouver: Copy

Zandi Atosa, AZARBAYJANI MOHAMMAD ALI, PEERI MAGHSOUD, HOSSEINI SEYED ALI. The Effect of Aerobic Training and Ozone Therapy on the Levels of MFN1 and DRP1 Gene Expression in the Heart Tissue of Rats with Osteoarthritis. GENE, CELL AND TISSUE[Internet]. 2020;7(4):0-0. Available from: https://sid.ir/paper/696673/en

IEEE: Copy

Atosa Zandi, MOHAMMAD ALI AZARBAYJANI, MAGHSOUD PEERI, and SEYED ALI HOSSEINI, “The Effect of Aerobic Training and Ozone Therapy on the Levels of MFN1 and DRP1 Gene Expression in the Heart Tissue of Rats with Osteoarthritis,” GENE, CELL AND TISSUE, vol. 7, no. 4, pp. 0–0, 2020, [Online]. Available: https://sid.ir/paper/696673/en

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