A Study of the Effect of the Aerobic Training Together with Stem Cells on the Levels of Some of the Apoptosis Indices of the Heart Tissue of the Male Wistar Rats of Osteoarthritis Model

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Jalilian Jasem; BEHPOUR NASER; HOSSEINPOUR DELAVAR SEDIGHEH; FARZANEGI PARVIN

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Journal: Jundishapur Scientific Medical Journal Year:2019 | Volume:18 | Issue:6 Page(s): 585-602

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Title

A Study of the Effect of the Aerobic Training Together with Stem Cells on the Levels of Some of the Apoptosis Indices of the Heart Tissue of the Male Wistar Rats of Osteoarthritis Model

Author(s)

Jalilian Jasem | BEHPOUR NASER | HOSSEINPOUR DELAVAR SEDIGHEH | FARZANEGI PARVIN | Issue Writer Certificate

Keywords

osteoarthritisQ1

apoptosisQ2

aerobic TrainingQ2

stem sellQ1

Abstract

Background and Objective: osteoarthritis is a common disease and painful arthritis with unknown etiology. In this study, the effects of mesenchymal stem cells and aerobic Training on apoptosis biomarkers (BAX and BCL2) in the heart tissue of osteoarthritic rats was investigated. Materials and Methods: In this experimental study, 42 male Wistar rats (age range 6-8 weeks and body weight of 250-300 g) were divided into two groups: osteoarthritic group (n=35) and healthy control group (n=7). osteoarthritis was induced in rats by surgery. then osteoarthritic rats were divided into five subgroups of seven including control, saline, stem cell, aerobic Training, and aerobic Training+stem cell groups. aerobic Training program was conducted for 8 weeks and 5 days a week. apoptosis biomarkers, including BAX and BCL2 proteins in the heart tissue of rats, were measured using ELISA kits. One-way ANOVA used to analyze the data. Results: BAX concentration was significantly higher in saline and unhealthy control groups compared to other groups and BCL2 concentration was significantly lower in saline and unhealthy control groups compared to other groups (P<0. 001). aerobic Training and stem cell, whether used separately or together, caused a significant increase in BCL2 concentration and a significant decrease in BAX concentration (P<0. 001). Conclusion: osteoarthritis caused an increase in heart cell apoptosis. Although stem sells have anti-apoptosis effects, they are more effective in treatment if used with aerobic Training.

Cites

The Effect of Aerobic Training and Ozone Therapy on the Levels of MFN1 and DRP1 Gene Expression in the Heart Tissue of Rats with Osteoarthritis

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APA: Copy

Jalilian, Jasem, BEHPOUR, NASER, HOSSEINPOUR DELAVAR, SEDIGHEH, & FARZANEGI, PARVIN. (2019). A Study of the Effect of the Aerobic Training Together with Stem Cells on the Levels of Some of the Apoptosis Indices of the Heart Tissue of the Male Wistar Rats of Osteoarthritis Model. JUNDISHAPUR SCIENTIFIC MEDICAL JOURNAL, 18(6 ), 585-602. SID. https://sid.ir/paper/367680/en

Vancouver: Copy

Jalilian Jasem, BEHPOUR NASER, HOSSEINPOUR DELAVAR SEDIGHEH, FARZANEGI PARVIN. A Study of the Effect of the Aerobic Training Together with Stem Cells on the Levels of Some of the Apoptosis Indices of the Heart Tissue of the Male Wistar Rats of Osteoarthritis Model. JUNDISHAPUR SCIENTIFIC MEDICAL JOURNAL[Internet]. 2019;18(6 ):585-602. Available from: https://sid.ir/paper/367680/en

IEEE: Copy

Jasem Jalilian, NASER BEHPOUR, SEDIGHEH HOSSEINPOUR DELAVAR, and PARVIN FARZANEGI, “A Study of the Effect of the Aerobic Training Together with Stem Cells on the Levels of Some of the Apoptosis Indices of the Heart Tissue of the Male Wistar Rats of Osteoarthritis Model,” JUNDISHAPUR SCIENTIFIC MEDICAL JOURNAL, vol. 18, no. 6 , pp. 585–602, 2019, [Online]. Available: https://sid.ir/paper/367680/en

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