THE ASSOCIATION STUDY OF RS17173608 SINGLE-NUCLEOTIDE POLYMORPHISM IN THE CHEMERIN GENE WITH GESTATIONAL DIABETES

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HSANVAND Z.; JALALI MASHAYEKHI F.; SADEGHI A.; REZVANFAR M.R.; GOODARZI M.T.

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Journal: Journal of Arak University Medical Sciences Year:2014 | Volume:17 | Issue:9 (90) Page(s): 27-36

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Title

THE ASSOCIATION STUDY OF RS17173608 SINGLE-NUCLEOTIDE POLYMORPHISM IN THE CHEMERIN GENE WITH GESTATIONAL DIABETES

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Keywords

CHEMERINQ1

GESTATIONAL DIABETESQ1

RS17173608 SNPQ2

Abstract

Background: GESTATIONAL DIABETES mellitus (GDM) is defined as glucose intolerance with first dignosis during pregnancy. There is some evidence indicating that CHEMERIN play a role in the development of GDM. In this study, for the first time, a possible association of rs17173608 polymorphism in the CHEMERIN gene with the risk of GDM in Arak population was investigated.Materials and Methods: In this case-control study, 120 GDM and 150 pregnant women with normal glucose tolerance were selected. GDM was confirmed by oral glucose tolerance according to the new IADPSG criteria. Genomic DNA was extracted from EDTA treated whole blood. The polymorphism of CHEMERIN gene was determined using tetra-amplification refractory mutation systempolymerase chain reaction (T-ARMS-PCR).Results: The genotype frequencies of TT, GT and GG at rs17173608 were respectively 81.7%, 17.5% and 0.8% in the GDM group and 73.3%, 25.3% and 1.3% in the control group. There were no statistical differences in genotype frequencies between case group and the control group.Also, allele frequencies in the GDM group (T, 90.4%, G 9.6%), did not differ significantly from the control group (T 96%, G 14%). No association was found between genotype frequencies and FBS, 1h, 2 h and BMI.Conclusion: The present study show that the rs17173608 polymorphism in the CHEMERIN gene is not associated with the development of glucose intolerance and GDM in the studied population.

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APA: Copy

HSANVAND, Z., JALALI MASHAYEKHI, F., SADEGHI, A., REZVANFAR, M.R., & GOODARZI, M.T.. (2014). THE ASSOCIATION STUDY OF RS17173608 SINGLE-NUCLEOTIDE POLYMORPHISM IN THE CHEMERIN GENE WITH GESTATIONAL DIABETES. ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ), 17(9 (90)), 27-36. SID. https://sid.ir/paper/69698/en

Vancouver: Copy

HSANVAND Z., JALALI MASHAYEKHI F., SADEGHI A., REZVANFAR M.R., GOODARZI M.T.. THE ASSOCIATION STUDY OF RS17173608 SINGLE-NUCLEOTIDE POLYMORPHISM IN THE CHEMERIN GENE WITH GESTATIONAL DIABETES. ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ)[Internet]. 2014;17(9 (90)):27-36. Available from: https://sid.ir/paper/69698/en

IEEE: Copy

Z. HSANVAND, F. JALALI MASHAYEKHI, A. SADEGHI, M.R. REZVANFAR, and M.T. GOODARZI, “THE ASSOCIATION STUDY OF RS17173608 SINGLE-NUCLEOTIDE POLYMORPHISM IN THE CHEMERIN GENE WITH GESTATIONAL DIABETES,” ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ), vol. 17, no. 9 (90), pp. 27–36, 2014, [Online]. Available: https://sid.ir/paper/69698/en

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