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Information Journal Paper

Title

The Effect of Piperine on MMP-9, VEGF, and E-cadherin Expression in Breast Cancer MCF-7 Cell Line

Pages

  112-119

Abstract

 Background: Vascular endothelial growth factor (VEGF), matrix metalloproteinase-9 (MMP-9), and E-cadherin play a vital role in the behavior of angiogenesis, metastasis, and invasion of breast tumor cells. Piperine, the main component of Piper Nigrum, has shown anti-cancer properties in various malignancies. This Study investigates the potential effect of Piperine on MMP-9, E-cadherin, and VEGF expression in breast cancer MCF-7 cell line. Methods: MTT assay was applied to assess the viability of MCF-7 cells. The mRNA levels of MMP-9, VEGF, and E-cadherin were assayed by qRT-PCR. Western blot was performed to identify the protein level of MMP-9. Results: MTT assay results showed that Piperine treatment (5, 10, 25, 50, 75, and 100 μ M) for 24 hours effectively inhibited cell viability of MCF-7 cells as compared with the control group. Furthermore, the gene expression of VEGF, MMP-9, and E-cadherin was dose-dependently suppressed by Piperine treatment (5, 10 and 25 μ M) (P<0. 05; P<0. 01). The results also indicated that Piperine (5, 10, and 25 μ M) significantly suppressed MMP-9 protein expression after 24 hours of Piperine treatment (P<0. 01). Conclusion: These results suggest that Piperine may prevent angiogenesis, migration, and invasion of MCF-7 cells by suppressing MMP-9 and VEGF, and by inducing E-cadherin expression. Hence, it may be a suitable candidate for designing new drugs in cancer therapy.

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    APA: Copy

    ZARE, ZAHRA, Nayerpour dizaj, Tina, Lohrasbi, Armaghan, Sheikhalishahi, Zakieh Sadat, Panji, Mohammad, Hosseinabadi, Fahimeh, NAJAFI, VAJIHEH, Abazari, Omid, ABBASI, MOJTABA, & Khanicheragh, Parisa. (2020). The Effect of Piperine on MMP-9, VEGF, and E-cadherin Expression in Breast Cancer MCF-7 Cell Line. BASIC & CLINICAL CANCER RESEARCH, 12(3), 112-119. SID. https://sid.ir/paper/697071/en

    Vancouver: Copy

    ZARE ZAHRA, Nayerpour dizaj Tina, Lohrasbi Armaghan, Sheikhalishahi Zakieh Sadat, Panji Mohammad, Hosseinabadi Fahimeh, NAJAFI VAJIHEH, Abazari Omid, ABBASI MOJTABA, Khanicheragh Parisa. The Effect of Piperine on MMP-9, VEGF, and E-cadherin Expression in Breast Cancer MCF-7 Cell Line. BASIC & CLINICAL CANCER RESEARCH[Internet]. 2020;12(3):112-119. Available from: https://sid.ir/paper/697071/en

    IEEE: Copy

    ZAHRA ZARE, Tina Nayerpour dizaj, Armaghan Lohrasbi, Zakieh Sadat Sheikhalishahi, Mohammad Panji, Fahimeh Hosseinabadi, VAJIHEH NAJAFI, Omid Abazari, MOJTABA ABBASI, and Parisa Khanicheragh, “The Effect of Piperine on MMP-9, VEGF, and E-cadherin Expression in Breast Cancer MCF-7 Cell Line,” BASIC & CLINICAL CANCER RESEARCH, vol. 12, no. 3, pp. 112–119, 2020, [Online]. Available: https://sid.ir/paper/697071/en

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