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Information Journal Paper

Title

EFFECTS OF ETHANOL PRECONDITIONING ON PENTYLENETETRAZOLE-INDUCED MEMORY IMPAIRMENT AND EXPRESSION OF NMDA RECEPTOR NR1 SUBUNIT MRNA IN RAT

Pages

  65-76

Abstract

 Background: Neuronal damage following SEIZUREs and EPILEPSY is one of the main causes of disabilities and mortality worldwide. In recent years, PRECONDITIONING has been introduced as a novel strategy for the prevention of brain damage. PRECONDITIONING is a phenomenon in which a minor noxious stimulus protects from a subsequent more severe insult. The aim of present study was to examine the effect of ETHANOL (Eth) PRECONDITIONING on PENTYLENETETRAZOLE (PTZ) -induced impairment memory in the inhibitory avoidance model.Material and Methods: This study was carried out on 45 adult male Wistar rats (180-200 g).Animals were assigned into five groups: Control, Eth 0.25, Eth 0.5, PTZ and Eth (0.5) +PTZ (n=9, for all groups). Eth-preconditioning was induced 6 days before the injection of PTZ. The animals were tested in a single trial step-through inhibitory test in two sessions (train and test). Then locomotor activity of rats was recorded in the open-field apparatus and NR1 mRNA expression in the hippocampus was measured by real-time PCR technique.Results: One-way ANOVA revealed that the ETHANOL PRECONDITIONING did not impair inhibitory memory. Further, post-test analyses showed that ETHANOL PRECONDITIONING significantly prevented from PTZ-induced memory impairment, and increased NR1 subunit mRNA expression in PTZ-induced memory impairment group. In addition, one-way ANOVA for the locomotor activity showed no significant difference between the groups.Conclusion: Our results showed that a pre-conditioning treatment with ETHANOL (0.5g/kg/day), 6 days before PTZ-induced memory impairment may provide a kind of neuroprotection in rats.

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    APA: Copy

    Alinaghipour, Azam, Tavassoli, Marziyeh, SEYED HOSSEINI, ELAHEH, & ARDJMAND, ABOLFAZL. (2017). EFFECTS OF ETHANOL PRECONDITIONING ON PENTYLENETETRAZOLE-INDUCED MEMORY IMPAIRMENT AND EXPRESSION OF NMDA RECEPTOR NR1 SUBUNIT MRNA IN RAT. ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ), 20(7 (124)), 65-76. SID. https://sid.ir/paper/69717/en

    Vancouver: Copy

    Alinaghipour Azam, Tavassoli Marziyeh, SEYED HOSSEINI ELAHEH, ARDJMAND ABOLFAZL. EFFECTS OF ETHANOL PRECONDITIONING ON PENTYLENETETRAZOLE-INDUCED MEMORY IMPAIRMENT AND EXPRESSION OF NMDA RECEPTOR NR1 SUBUNIT MRNA IN RAT. ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ)[Internet]. 2017;20(7 (124)):65-76. Available from: https://sid.ir/paper/69717/en

    IEEE: Copy

    Azam Alinaghipour, Marziyeh Tavassoli, ELAHEH SEYED HOSSEINI, and ABOLFAZL ARDJMAND, “EFFECTS OF ETHANOL PRECONDITIONING ON PENTYLENETETRAZOLE-INDUCED MEMORY IMPAIRMENT AND EXPRESSION OF NMDA RECEPTOR NR1 SUBUNIT MRNA IN RAT,” ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ), vol. 20, no. 7 (124), pp. 65–76, 2017, [Online]. Available: https://sid.ir/paper/69717/en

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