THE EFFECTIVENESS OF METOCLOPRAMIDE, DEXAMETHASONE AND PROPOFOL IN CONTROLLING INTRAOPERATIVE NAUSEA AND VOMITING DURING SPINAL ANESTHESIA FOR EMERGENCY CESAREAN SECTION

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PAZOUKI S.; NOROUZI A.; ESKANDARI M.; MEMARI S.; ZARGANJ FARD A.

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Journal Paper

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Journal: Journal of Arak University Medical Sciences Year:2006 | Volume:9 | Issue:3 (36) Page(s): 9-15

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Title

THE EFFECTIVENESS OF METOCLOPRAMIDE, DEXAMETHASONE AND PROPOFOL IN CONTROLLING INTRAOPERATIVE NAUSEA AND VOMITING DURING SPINAL ANESTHESIA FOR EMERGENCY CESAREAN SECTION

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Keywords

SPINAL ANESTHESIAQ3

CESAREAN SECTIONQ3

INTRAOPERATIVE VOMITINGQ3

PROPOFOLQ3

METOCLOPRAMIDEQ2

Abstract

Introduction: SPINAL ANESTHESIA is a conventional way of anesthesia for CESAREAN SECTION (CS), which nausea and vomiting is a common complication of it. METOCLOPRAMIDE is the standard medication used for preventing intraoperative nausea and vomiting (IONV). Because of extrapyromidal side effects of METOCLOPRAMIDE and known antiemetic effects of low-dose PROPOFOL and Dexamethasone, this study was performed to compare the effectiveness of these drugs for preventing IONV.Materials and Methods: This study, is a randomized clinical trial which is done on 144 parturients who were admitted for emergency CS. Patients were divided randomly into four groups and received: METOCLOPRAMIDE 0.1 mg/kg IV, Dexamethasone 150 μg/kg IV, PROPOFOL 0.1mg/kg every 5 minutes from clamping umbilical cord till the end of operation and the fourth group received 2 ml distilled water. During the operation parturients were monitored for IONV. Data was analyzed using Kruskal-Wallis and one way ANOVA. Results: The Number of patients having nausea was lowest in PROPOFOL and highest in Dexamethasone group. There was no statistical significant difference between Dexamethasone and placebo groups. The lowest rate of vomiting was in METOCLOPRAMIDE and PROPOFOL groups and there was no significant difference between them. Also the lowest level of retching was in the Prepofol group.Conclusion: According to results, the antiemetic effects of PROPOFOL and METOCLOPRAMIDE are similar. Amount of retching in PROPOFOL was slightly lower than METOCLOPRAMIDE and administration of PROPOFOL was simple, cheap and without serious complications, so we recommend it for emergency CS.

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References

THE COMPARISON OF DEXAMETHASONE AND METOCLOPRAMIDE EFFECTS ON POSTOPERATIVE NAUSEA AND VOMITING

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APA: Copy

PAZOUKI, S., NOROUZI, A., ESKANDARI, M., MEMARI, S., & ZARGANJ FARD, A.. (2006). THE EFFECTIVENESS OF METOCLOPRAMIDE, DEXAMETHASONE AND PROPOFOL IN CONTROLLING INTRAOPERATIVE NAUSEA AND VOMITING DURING SPINAL ANESTHESIA FOR EMERGENCY CESAREAN SECTION. ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ), 9(3 (36)), 9-15. SID. https://sid.ir/paper/69770/en

Vancouver: Copy

PAZOUKI S., NOROUZI A., ESKANDARI M., MEMARI S., ZARGANJ FARD A.. THE EFFECTIVENESS OF METOCLOPRAMIDE, DEXAMETHASONE AND PROPOFOL IN CONTROLLING INTRAOPERATIVE NAUSEA AND VOMITING DURING SPINAL ANESTHESIA FOR EMERGENCY CESAREAN SECTION. ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ)[Internet]. 2006;9(3 (36)):9-15. Available from: https://sid.ir/paper/69770/en

IEEE: Copy

S. PAZOUKI, A. NOROUZI, M. ESKANDARI, S. MEMARI, and A. ZARGANJ FARD, “THE EFFECTIVENESS OF METOCLOPRAMIDE, DEXAMETHASONE AND PROPOFOL IN CONTROLLING INTRAOPERATIVE NAUSEA AND VOMITING DURING SPINAL ANESTHESIA FOR EMERGENCY CESAREAN SECTION,” ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ), vol. 9, no. 3 (36), pp. 9–15, 2006, [Online]. Available: https://sid.ir/paper/69770/en

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