Comparative Evaluation of Linezolid and Teicoplanin in the Treatment of Ventilator-Associated MRSA Pneumonia: A Single-Center Experience

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Hasan Md. Jahidul; Tun Nessa Shahzadi Sayeeda; Rabbani Raihan

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Journal: International Journal of Infection Year:2020 | Volume:7 | Issue:3 Page(s): 0-0

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Title

Comparative Evaluation of Linezolid and Teicoplanin in the Treatment of Ventilator-Associated MRSA Pneumonia: A Single-Center Experience

Author(s)

Hasan Md. Jahidul | Tun Nessa Shahzadi Sayeeda | Rabbani Raihan | Issue Writer Certificate

Keywords

Ventilator-Associated Pneumonia

Methicillin-Resistant Staphylococcus aureus

Linezolid

Teicoplanin

Adverse Drug Reaction

Critically Ill Patients

Abstract

Background: Ventilator-Associated Pneumonia (VAP) caused by Methicillin-Resistant Staphylococcus aureus (MRSA) is a serious infection in an intensive care unit (ICU). Ventilator-associated MRSA pneumonia (VAMP) in Critically Ill Patients causes a high rate of mortality. Objectives: This study mainly aimed to compare the clinical outcomes and associated drug safety perspective of Linezolid and Teicoplanin in VAMP treatment. Methods: This retrospective study included 98 adult ICU patients with VAMP, where 42 patients (LZD group) and 56 patients (TPN group) received a standard dose of Linezolid and Teicoplanin, respectively, for their VAMP treatment. Adverse reactions associated with Linezolid and Teicoplanin were considered. Clinical outcomes and 30-day mortality rates were compared in both groups. Results: The LZD group showed a higher MRSA eradication rate (97%, n = 34) than the TPN group (94. 3%, n = 53) (P = 0. 034). The Linezolid and Teicoplanin therapy was suddenly discontinued in 19% and 5. 3% of the patients in the LZD and TPN groups, respectively, before completing the full duration of antibiotic therapy due to developed Adverse Drug Reactions (ADRs), including thrombocytopenia (LZD/TPN groups: 7/1 event), tachycardia (LZD group: 1 event), and nephrotoxicity (TPN group: 2 events). This discontinuation increased the total duration of antibiotic therapy in 19% (n = 42) and 5. 3% (n = 56) of the patients (P = 0. 034) in the LZD and TPN groups, respectively. Conclusions: VAMP is a life-threatening event in critically ill ICU patients worldwide. In this study, Teicoplanin showed better clinical outcomes with a certain higher level of drug safety compared to Linezolid in the treatment of ventilator-associated MRSA pneumonia.

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APA: Copy

Hasan, Md. Jahidul, Tun Nessa, Shahzadi Sayeeda, & Rabbani, Raihan. (2020). Comparative Evaluation of Linezolid and Teicoplanin in the Treatment of Ventilator-Associated MRSA Pneumonia: A Single-Center Experience. INTERNATIONAL JOURNAL OF INFECTION, 7(3), 0-0. SID. https://sid.ir/paper/697934/en

Vancouver: Copy

Hasan Md. Jahidul, Tun Nessa Shahzadi Sayeeda, Rabbani Raihan. Comparative Evaluation of Linezolid and Teicoplanin in the Treatment of Ventilator-Associated MRSA Pneumonia: A Single-Center Experience. INTERNATIONAL JOURNAL OF INFECTION[Internet]. 2020;7(3):0-0. Available from: https://sid.ir/paper/697934/en

IEEE: Copy

Md. Jahidul Hasan, Shahzadi Sayeeda Tun Nessa, and Raihan Rabbani, “Comparative Evaluation of Linezolid and Teicoplanin in the Treatment of Ventilator-Associated MRSA Pneumonia: A Single-Center Experience,” INTERNATIONAL JOURNAL OF INFECTION, vol. 7, no. 3, pp. 0–0, 2020, [Online]. Available: https://sid.ir/paper/697934/en

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