STUDY THE EFFECT OF 4 WEEKS OF SPECIAL AEROBIC TRAINING ON CBS AND SAMLEVELS IN HIPPOCAMPUS OF RATS WITH ALZHEIMER-INDUCED DISEASE WITH Aβ1-42 INJECTION

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azimi farhad; SIAHKOUHIAN MAREFAT; SEIFI SKISHAHR FARNAZ; AFROUNDEH ROGHAYEH

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Journal: ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ) Year:2018 | Volume:20 | Issue:12 (129) Page(s): 51-62

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Title

STUDY THE EFFECT OF 4 WEEKS OF SPECIAL AEROBIC TRAINING ON CBS AND SAMLEVELS IN HIPPOCAMPUS OF RATS WITH ALZHEIMER-INDUCED DISEASE WITH Aβ1-42 INJECTION

Author(s)

azimi farhad | SIAHKOUHIAN MAREFAT | SEIFI SKISHAHR FARNAZ | AFROUNDEH ROGHAYEH | Issue Writer Certificate

Keywords

AEROBIC EXERCISEQ1

ALZHEIMER'S DISEASEQ1

BETA-AMYLOIDQ1

CBSQ1

HYDROGEN SULFIDEQ1

SAMQ1

Abstract

Background: H2S plays a key role in the pathogenesis of the Alzheimer’s disease. The aim of the present study was to investigate the effects of 4 weeks of the special aerobic training after induction of Alzheimer’s disease by Ab1-42 injection on CBS and SAM levels in hippocampus of Wistar male rats.Materials and Methods: Twenty male Wistar rats (8 weeks old and weight 195 ± 20 g) were divided into four groups including: healthy control, Alzheimer’s control, Alzheimer’s+training and sham. To induce Alzheimer’s disease, Ab1-42 was infused into the hippocampus of rats. Training group trained for 4-week. For data analysis, one-way ANOVA was used and Eta and Omega squared tests were used to determine the effect size (p<0.05).Results: Findings revealed that 4 weeks of special aerobic training increased significantly the CBS and SAM levels in hippocampus of Alzheimer’s rats compared to the control Alzheimer’s rats (ES=53; p=0.007, ES=92.22; p=0.001). Also, we showed 4 weeks of special aerobic training increased CBS level in hippocampus of Alzheimer’s rats compared to the healthy cotrol group (ES=44.07; p=0.014).Conclusion: It seems that the special aerobic training can be used as a useful no npharmacologically effective therapeutic treatment for Alzheimer's patients through positive regulation of HYDROGEN SULFIDE via CBS and SAM enzymes.

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APA: Copy

azimi, farhad, SIAHKOUHIAN, MAREFAT, SEIFI SKISHAHR, FARNAZ, & AFROUNDEH, ROGHAYEH. (2018). STUDY THE EFFECT OF 4 WEEKS OF SPECIAL AEROBIC TRAINING ON CBS AND SAMLEVELS IN HIPPOCAMPUS OF RATS WITH ALZHEIMER-INDUCED DISEASE WITH Aβ1-42 INJECTION. ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ), 20(12 (129) ), 51-62. SID. https://sid.ir/paper/69798/en

Vancouver: Copy

azimi farhad, SIAHKOUHIAN MAREFAT, SEIFI SKISHAHR FARNAZ, AFROUNDEH ROGHAYEH. STUDY THE EFFECT OF 4 WEEKS OF SPECIAL AEROBIC TRAINING ON CBS AND SAMLEVELS IN HIPPOCAMPUS OF RATS WITH ALZHEIMER-INDUCED DISEASE WITH Aβ1-42 INJECTION. ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ)[Internet]. 2018;20(12 (129) ):51-62. Available from: https://sid.ir/paper/69798/en

IEEE: Copy

farhad azimi, MAREFAT SIAHKOUHIAN, FARNAZ SEIFI SKISHAHR, and ROGHAYEH AFROUNDEH, “STUDY THE EFFECT OF 4 WEEKS OF SPECIAL AEROBIC TRAINING ON CBS AND SAMLEVELS IN HIPPOCAMPUS OF RATS WITH ALZHEIMER-INDUCED DISEASE WITH Aβ1-42 INJECTION,” ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ), vol. 20, no. 12 (129) , pp. 51–62, 2018, [Online]. Available: https://sid.ir/paper/69798/en

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