The Effect of Two Types of Training Programs on the Expression of TrkB, Bax and Bcl-2 Genes in Male Rats After Induction of Cerebral Ischemia

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Sarhadi Sara; SHAHIDI FERESHTEH; KESHAVARZI ZAKIEH

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Journal: Gene, Cell and Tissue Year:2020 | Volume:7 | Issue:2 Page(s): 0-0

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Title

The Effect of Two Types of Training Programs on the Expression of TrkB, Bax and Bcl-2 Genes in Male Rats After Induction of Cerebral Ischemia

Author(s)

Sarhadi Sara | SHAHIDI FERESHTEH | KESHAVARZI ZAKIEH | Issue Writer Certificate

Keywords

Exercise

Apoptosis

Ischemia

Bax

Bcl2

TrkB

Abstract

Background: Physical activity and dynamic lifestyle play an important role in the prevention and treatment of some common neurological diseases. Onevaluable approach to increasing healthandreducing braindamageis to performanExerciseandphysical activity. Objectives: The aim of the present study was to investigate the effect of Exercise pre-training on the intervening factors and complications of cerebral Ischemia. Methods: In this study, forty Wistar rats were randomly divided into four groups, including (1) endurance training, (2) endurancecognitive training, (3) Ischemia, and (4) control. The training was performed for 3 weeks. After the last training session, the rats had to undergo cerebral Ischemia. The Ischemia was induced by occlusion of both common carotid arteries for 30 min. Real-time PCR method was used to measure the expression level of TrkB, Bax, and Bcl-2 genes. Results: The levels of TrkB gene expression were significantly increased in the endurance training and endurance-cognitive training groups compared to the Ischemia and control groups (P < 0. 05). There was a significant increase in the levels of Bcl-2 gene expression in the endurance training group compared to the Ischemia group as well as the endurance-cognitive group compared to the Ischemia and control groups (P < 0. 05). Also, the levels of Bax gene expression in the endurance training and endurance-cognitive groups were significantly lower than the control group (P < 0. 05). Conclusions: This study showed that Exercise as a preconditioning stimulus has neuroprotective effects against cerebral Ischemia.

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APA: Copy

Sarhadi, Sara, SHAHIDI, FERESHTEH, & KESHAVARZI, ZAKIEH. (2020). The Effect of Two Types of Training Programs on the Expression of TrkB, Bax and Bcl-2 Genes in Male Rats After Induction of Cerebral Ischemia. GENE, CELL AND TISSUE, 7(2), 0-0. SID. https://sid.ir/paper/697997/en

Vancouver: Copy

Sarhadi Sara, SHAHIDI FERESHTEH, KESHAVARZI ZAKIEH. The Effect of Two Types of Training Programs on the Expression of TrkB, Bax and Bcl-2 Genes in Male Rats After Induction of Cerebral Ischemia. GENE, CELL AND TISSUE[Internet]. 2020;7(2):0-0. Available from: https://sid.ir/paper/697997/en

IEEE: Copy

Sara Sarhadi, FERESHTEH SHAHIDI, and ZAKIEH KESHAVARZI, “The Effect of Two Types of Training Programs on the Expression of TrkB, Bax and Bcl-2 Genes in Male Rats After Induction of Cerebral Ischemia,” GENE, CELL AND TISSUE, vol. 7, no. 2, pp. 0–0, 2020, [Online]. Available: https://sid.ir/paper/697997/en

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