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Title

ASSOCIATION OF THE +49 A/G POLYMORPHISM OF CTLA4 GENE WITH IDIOPATHIC RECURRENT SPONTANEOUS ABORTION IN WOMEN IN SOUTHWEST OF IRAN

Pages

  151-156

Abstract

 Background: Survival of the semi-allograft fetus during pregnancy opens a new area for the immunological based causes of RECURRENT SPONTANEOUS ABORTION (RSA). Cytotoxic T lymphocyte-associated antigen 4 (CTLA4) is a negative regulator of the T-cell activation, which may modulate peripheral self-tolerance of the allogeneic fetus.The present study aimed to investigate the+49 A/GCTLA4 genetic POLYMORPHISM and predisposition to RSA.Methods: The total participants were 120 women with at least two miscarriages and 120 healthy post-menopausal women as the control group. The+49 A/G POLYMORPHISM was genotyped using PCR-RFLP method. Required demographic information was collected through filling out a questionnaire. The obtained data were fed into SPSS software version 16.Results: The results showed a significant association between the minor alleles (G) with the decreased risk of the RSA. The frequency of the G allele in controls and patients was 25% and 12%, respectively. A GG genotype in the co-dominance model (OR: 0.25, 95%CI: 0.09-0.66) and in the dominant model for allele G (GG+AGvs.AA) (OR: 0.84, 95%CI: 0.8-0.87) showed significant association with RSA by imposing the protective role. The frequency of miscarriage is significantly (p=0.04) higher among the relatives of RSA women (33.3%) in comparison with the women in the control group (21.7%).Conclusion: It can be concluded that+49G allele may act as a dominant allele and reduce the risk of RSA. Family history of miscarriage increased the risk of RSA among women.

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    APA: Copy

    RASTI, ZARNEGAR, & NASIRI, MAHBOOBEH. (2016). ASSOCIATION OF THE +49 A/G POLYMORPHISM OF CTLA4 GENE WITH IDIOPATHIC RECURRENT SPONTANEOUS ABORTION IN WOMEN IN SOUTHWEST OF IRAN. JOURNAL OF REPRODUCTION AND INFERTILITY, 17(3), 151-156. SID. https://sid.ir/paper/698325/en

    Vancouver: Copy

    RASTI ZARNEGAR, NASIRI MAHBOOBEH. ASSOCIATION OF THE +49 A/G POLYMORPHISM OF CTLA4 GENE WITH IDIOPATHIC RECURRENT SPONTANEOUS ABORTION IN WOMEN IN SOUTHWEST OF IRAN. JOURNAL OF REPRODUCTION AND INFERTILITY[Internet]. 2016;17(3):151-156. Available from: https://sid.ir/paper/698325/en

    IEEE: Copy

    ZARNEGAR RASTI, and MAHBOOBEH NASIRI, “ASSOCIATION OF THE +49 A/G POLYMORPHISM OF CTLA4 GENE WITH IDIOPATHIC RECURRENT SPONTANEOUS ABORTION IN WOMEN IN SOUTHWEST OF IRAN,” JOURNAL OF REPRODUCTION AND INFERTILITY, vol. 17, no. 3, pp. 151–156, 2016, [Online]. Available: https://sid.ir/paper/698325/en

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