INVESTIGATION OF PROTECTIVE EFFECT OF HYDROALCOHOLIC EXTRACT OF GINGER ON CYTOTOXITY OF SILVER NANOPARTICLES ON HEPATIC ENZYMES, HEMATHOLOGIC FACTORS, BLOOD OXIDATIVE STRESS MARKERS AND HEPATIC APAPTOSIS IN BALB-C MICE

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SHARIATZADEH SEYEDMEHDI; KAZEMIPOUR NASRIN; NAZIFI SAEED

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Journal: ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ) Year:2016 | Volume:19 | Issue:9 (114) Page(s): 78-87

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Title

INVESTIGATION OF PROTECTIVE EFFECT OF HYDROALCOHOLIC EXTRACT OF GINGER ON CYTOTOXITY OF SILVER NANOPARTICLES ON HEPATIC ENZYMES, HEMATHOLOGIC FACTORS, BLOOD OXIDATIVE STRESS MARKERS AND HEPATIC APAPTOSIS IN BALB-C MICE

Author(s)

SHARIATZADEH SEYEDMEHDI | KAZEMIPOUR NASRIN | NAZIFI SAEED | Issue Writer Certificate

Keywords

APOPTOSISQ2

GINGER EXTRACTQ1

HEMATOLOGICAL FACTORSQ1

HEPATIC ENZYMESQ2

OXIDATIVE STRESSQ2

SILVER NANOPARTICLESQ2

Abstract

Background: SILVER NANOPARTICLES are capable of inducing toxicity in living organisms. Silvernanoparticles can induce some effect in the liver. Thus SILVER NANOPARTICLES, due to their wide spreadeffects, can also affect on hepatic, hematological, and OXIDATIVE STRESS factors. Ginger because of itspowerful antioxidantal compounds can influence the toxicity effects of SILVER NANOPARTICLES in differentparts of the body. The aim of this study was to investigate the protective effect of hydroalchoholic extractof ginger on cytotoxic SILVER NANOPARTICLES on enzymes, hematological parameters, blood OXIDATIVE STRESSmarkers, and hepatic APOPTOSIS in Balb-c mice.Materials and Methods: In this study, 48 rats of Balb-c race Syrians were selected and devidedinto 4 groups, each consisting of 12. They were treated for a period of 35 days; the first group (control)received distilled water, the second group received nano silver, the third group received GINGER EXTRACT, and the fourth group received both nanosilver and GINGER EXTRACT at the same time. Bleeding was done tomeasure HEMATOLOGICAL FACTORS, liver enzymes, and OXIDATIVE STRESS; then liver tissue was removed forevaluation of APOPTOSIS. Data were compared using SPSS software and one-way ANOVA.Results: Enzymes AST, ALT, ALP, GGT and LDH as liver factors showed significantdifferences in the groups of the study. HEMATOLOGICAL FACTORS including of WBC, RBC, Hb, HCT, MCV, MCH, Plt, Lymphocyte and Monocyte showed significant differences in all the groups. Of OXIDATIVE STRESS factors, only GPX showed significant difference between groups, while no significantdifference was observed in other OXIDATIVE STRESS parameters in the blood. Changes in APOPTOSIS showedsignificant differences in all groups of the study.Conclusion: Based on the findings the study, SILVER NANOPARTICLES with their side effects indifferent parts of the body can induce changes in various factors and enzymes. Ginger can compensate, and modify to some extent these side effects. Such effectiveness of ginger can probably be due to itsspecial ingredients.

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APA: Copy

SHARIATZADEH, SEYEDMEHDI, KAZEMIPOUR, NASRIN, & NAZIFI, SAEED. (2016). INVESTIGATION OF PROTECTIVE EFFECT OF HYDROALCOHOLIC EXTRACT OF GINGER ON CYTOTOXITY OF SILVER NANOPARTICLES ON HEPATIC ENZYMES, HEMATHOLOGIC FACTORS, BLOOD OXIDATIVE STRESS MARKERS AND HEPATIC APAPTOSIS IN BALB-C MICE. ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ), 19(9 (114)), 78-87. SID. https://sid.ir/paper/69837/en

Vancouver: Copy

SHARIATZADEH SEYEDMEHDI, KAZEMIPOUR NASRIN, NAZIFI SAEED. INVESTIGATION OF PROTECTIVE EFFECT OF HYDROALCOHOLIC EXTRACT OF GINGER ON CYTOTOXITY OF SILVER NANOPARTICLES ON HEPATIC ENZYMES, HEMATHOLOGIC FACTORS, BLOOD OXIDATIVE STRESS MARKERS AND HEPATIC APAPTOSIS IN BALB-C MICE. ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ)[Internet]. 2016;19(9 (114)):78-87. Available from: https://sid.ir/paper/69837/en

IEEE: Copy

SEYEDMEHDI SHARIATZADEH, NASRIN KAZEMIPOUR, and SAEED NAZIFI, “INVESTIGATION OF PROTECTIVE EFFECT OF HYDROALCOHOLIC EXTRACT OF GINGER ON CYTOTOXITY OF SILVER NANOPARTICLES ON HEPATIC ENZYMES, HEMATHOLOGIC FACTORS, BLOOD OXIDATIVE STRESS MARKERS AND HEPATIC APAPTOSIS IN BALB-C MICE,” ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ), vol. 19, no. 9 (114), pp. 78–87, 2016, [Online]. Available: https://sid.ir/paper/69837/en

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