ASSOCIATION OF GADD45A GENE POLYMORPHISM WITH SYSTEMIC LUPUS ERYTHEMATOSUS DISEASE AMONG PATIENTS IN SOUTH OF IRAN

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RAHIMI SHEKOOFEH; NASIRI MAHBOOBEH; ARIANNIA SAEIDEH; FARROKH SERESHT REZA

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Journal: Journal of Arak University Medical Sciences Year:2016 | Volume:19 | Issue:9 (114) Page(s): 59-66

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Title

ASSOCIATION OF GADD45A GENE POLYMORPHISM WITH SYSTEMIC LUPUS ERYTHEMATOSUS DISEASE AMONG PATIENTS IN SOUTH OF IRAN

Author(s)

RAHIMI SHEKOOFEH | NASIRI MAHBOOBEH | ARIANNIA SAEIDEH | FARROKH SERESHT REZA | Issue Writer Certificate

Keywords

GADD45AQ2

IRANQ2

POLYMORPHISMQ1

SYSTEMIC LUPUS ERYTHEMATOSUSQ1

Abstract

Background: SYSTEMIC LUPUS ERYTHEMATOSUS (SLE) is an autoimmune disease with broad clinical manifestations, but unclear etiology. Extensive tissue damage occurs due to the production of autoantibody against nuclear and cytoplasmic antigens. Regarding the involvement of GADD45A gene in cell cycle control, T-cell proliferation suppression, and genome epigenetic regulation, this case- control study was done for the first time to evaluate the association of rs581000 POLYMORPHISM in 5’ near gene with the risk of SLE among patients in south of IRAN.Materials and Methods: This study was performed on 102 patients with SLE in comparison with 118 healthy controls. Genotyping of the GADD45A rs581000 POLYMORPHISM was performed using TARMS PCR.Results: The T allele was significantly more frequent in the controls (0.13) than in the patients (0.01) with SLE (p<0.001). The frequency of genotypes carrying at least one C allele (CC+CG) was higher in control group (14.4%) compared to patient group (1%), and this allele showed protective effect against the risk of SLE (p<0.001, CI: 0.009-0.5, OR=0.06) Conclusion: It seems that GADD45A rs581000 POLYMORPHISM involved in the SLE pathogenesis.

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APA: Copy

RAHIMI, SHEKOOFEH, NASIRI, MAHBOOBEH, ARIANNIA, SAEIDEH, & FARROKH SERESHT, REZA. (2016). ASSOCIATION OF GADD45A GENE POLYMORPHISM WITH SYSTEMIC LUPUS ERYTHEMATOSUS DISEASE AMONG PATIENTS IN SOUTH OF IRAN. ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ), 19(9 (114)), 59-66. SID. https://sid.ir/paper/69843/en

Vancouver: Copy

RAHIMI SHEKOOFEH, NASIRI MAHBOOBEH, ARIANNIA SAEIDEH, FARROKH SERESHT REZA. ASSOCIATION OF GADD45A GENE POLYMORPHISM WITH SYSTEMIC LUPUS ERYTHEMATOSUS DISEASE AMONG PATIENTS IN SOUTH OF IRAN. ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ)[Internet]. 2016;19(9 (114)):59-66. Available from: https://sid.ir/paper/69843/en

IEEE: Copy

SHEKOOFEH RAHIMI, MAHBOOBEH NASIRI, SAEIDEH ARIANNIA, and REZA FARROKH SERESHT, “ASSOCIATION OF GADD45A GENE POLYMORPHISM WITH SYSTEMIC LUPUS ERYTHEMATOSUS DISEASE AMONG PATIENTS IN SOUTH OF IRAN,” ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ), vol. 19, no. 9 (114), pp. 59–66, 2016, [Online]. Available: https://sid.ir/paper/69843/en

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