The Polymorphisms of Fcγ RIIB Gene in rs1050501 and Fcγ RIIIA Gene in rs396991 and their association with Systemic Lupus Erythematous Disease Activity Index

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KARIMIFAR MANSOOR; KARIMZADEH HADI; Faragzadegan Ziba; AKBARI KHOSRO; Moosaeepour Mohammad; ABOLFATHI FARSHID

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Journal: JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S) Year:2019 | Volume:37 | Issue:521 Page(s): 310-315

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Title

The Polymorphisms of Fcγ RIIB Gene in rs1050501 and Fcγ RIIIA Gene in rs396991 and their association with Systemic Lupus Erythematous Disease Activity Index

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Systemic lupus erythematosusQ2

GenotypeQ2

Genetic polymorphismQ1

Abstract

Background: Systemic lupus erythematous (SLE) is a chronic disease with unknown etiology which can involve different body organs. Polymorphism in Fcγ receptors have been identified as a genetic susceptibility factor to SLE and other autoimmune diseases. This study aimed to identify Fcγ RIIB Genotype in rs10550501 and Fcγ RIIIA Genotype in rs396991, as well as their association with SLE Disease Activity Index (SLEDAI). Methods: Eighty clinically diagnosed patients with SLE based on the American College of Rheumatology (ACR) criteria were included. High-resolution melt-polymerase chain reaction (HRM-PCR) method was used to detect Fcγ RIIB and Fcγ RIIIA polymorphism. Disease activity was assessed using SLEDAI. Data were analyzed using SPSS software. Findings: Of the eighty patients, 90% were women, and 10% were men. Minimum and maximum SLEDAI scores were 0 and 51, respectively, with a mean of 21. 1. Among the patients with SLE, Fcγ RIIB frequency was 37. 5 % for TT Genotype and 31. 25% for CT and CC Genotypes. There was no significant association between Fcγ RIIB Genotype and SLEDAI (P = 0. 557). Fcγ RIIIA frequency was 47. 5% for TT, 31. 25% for CT, and 21. 25 for GG Genotype. There was a significant association between Fcγ RIIIA polymorphism and SLEDAI (P = 0. 029). Conclusion: The Genotypes in rs1050501 position do not have any effect on SLE disease severity. TG Genotype in rs396991 has a protective effect in SLE.

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APA: Copy

KARIMIFAR, MANSOOR, KARIMZADEH, HADI, Faragzadegan, Ziba, AKBARI, KHOSRO, Moosaeepour, Mohammad, & ABOLFATHI, FARSHID. (2019). The Polymorphisms of Fcγ RIIB Gene in rs1050501 and Fcγ RIIIA Gene in rs396991 and their association with Systemic Lupus Erythematous Disease Activity Index. JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S), 37(521 ), 310-315. SID. https://sid.ir/paper/365879/en

Vancouver: Copy

KARIMIFAR MANSOOR, KARIMZADEH HADI, Faragzadegan Ziba, AKBARI KHOSRO, Moosaeepour Mohammad, ABOLFATHI FARSHID. The Polymorphisms of Fcγ RIIB Gene in rs1050501 and Fcγ RIIIA Gene in rs396991 and their association with Systemic Lupus Erythematous Disease Activity Index. JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S)[Internet]. 2019;37(521 ):310-315. Available from: https://sid.ir/paper/365879/en

IEEE: Copy

MANSOOR KARIMIFAR, HADI KARIMZADEH, Ziba Faragzadegan, KHOSRO AKBARI, Mohammad Moosaeepour, and FARSHID ABOLFATHI, “The Polymorphisms of Fcγ RIIB Gene in rs1050501 and Fcγ RIIIA Gene in rs396991 and their association with Systemic Lupus Erythematous Disease Activity Index,” JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S), vol. 37, no. 521 , pp. 310–315, 2019, [Online]. Available: https://sid.ir/paper/365879/en

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