مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Information Journal Paper

Title

Aqueous Cannabis Extract Prevents Ethylene Glycol-induced Renal Calcium Crystallization

Pages

  8-15

Abstract

 Background: Some plant extracts can prevent kidney stone formation in a dosedependent manner. In our study, we aimed to investigate the protective role of Cannabis sativa aqueous extraction on calcium oxalate formation in Ethylene Glycolinduced Rats. Materials and Methods: To evaluate anti-urolithiasis, variations of the main risk factors (citrate, phosphorous, calcium, and Ph) have been evaluated in 24-hour urine samples of Rats one day before the end of the experiment. Rats were divided into 4 groups: group 1 was administered regular drinking water; group 2 was administered 1% Ethylene Glycol in drinking water, group 3 was administered 100 mg/kg of Cannabis sativa extract for oral administration by gavage along with drinking water containing 1% Ethylene Glycol; and group 4 was administered 200 mg/kg of Cannabis sativa extract by gavage along with drinking water containing 1% Ethylene Glycol. Finally, histopathological slides from the kidney were also evaluated. Results: Results showed that 100 mg/kg and 200 mg/kg doses of Cannabis sativa extract significantly reduced the mentioned risk factors in comparison with Ethylene Glycol-treated Rats (p<0. 05). Conclusion: Histopathological slides showed reduced calcifications with extract treatment at 200 mg/kg of Cannabis sativa. Thus, this antioxidant herb can prevent kidney stone formation. These findings pave the way for new therapy.

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    APA: Copy

    AMOUZESHI, AHMAD, Moossavi, Seyedeh Zahra, JAVADMOOSAVI, SEYED YOOSEF, ZARDAST, MAHMOUD, MALEKANEH, MOHAMMAD, ESMAILI, SAJAD, Taneh, Abdolghader, Lotfi, Nasim, Moossavi, Maryam, & HOSHYAR, REYHANE. (2019). Aqueous Cannabis Extract Prevents Ethylene Glycol-induced Renal Calcium Crystallization. RESEARCH IN MOLECULAR MEDICINE, 7(1), 8-15. SID. https://sid.ir/paper/698575/en

    Vancouver: Copy

    AMOUZESHI AHMAD, Moossavi Seyedeh Zahra, JAVADMOOSAVI SEYED YOOSEF, ZARDAST MAHMOUD, MALEKANEH MOHAMMAD, ESMAILI SAJAD, Taneh Abdolghader, Lotfi Nasim, Moossavi Maryam, HOSHYAR REYHANE. Aqueous Cannabis Extract Prevents Ethylene Glycol-induced Renal Calcium Crystallization. RESEARCH IN MOLECULAR MEDICINE[Internet]. 2019;7(1):8-15. Available from: https://sid.ir/paper/698575/en

    IEEE: Copy

    AHMAD AMOUZESHI, Seyedeh Zahra Moossavi, SEYED YOOSEF JAVADMOOSAVI, MAHMOUD ZARDAST, MOHAMMAD MALEKANEH, SAJAD ESMAILI, Abdolghader Taneh, Nasim Lotfi, Maryam Moossavi, and REYHANE HOSHYAR, “Aqueous Cannabis Extract Prevents Ethylene Glycol-induced Renal Calcium Crystallization,” RESEARCH IN MOLECULAR MEDICINE, vol. 7, no. 1, pp. 8–15, 2019, [Online]. Available: https://sid.ir/paper/698575/en

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