The Association of Non-Steroidal Anti-Inflammatory Drugs with COVID-19 Severity and Mortality

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SAMIMAGHAM HAMIDREZA; ARABI MOHSEN; Hooshyar Dariush; KAZEMI JAHROMI MITRA

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Journal Paper

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Journal: Archives of Clinical Infectious Diseases Year:2020 | Volume:15 | Issue:4 Page(s): 0-0

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Title

The Association of Non-Steroidal Anti-Inflammatory Drugs with COVID-19 Severity and Mortality

Author(s)

SAMIMAGHAM HAMIDREZA | ARABI MOHSEN | Hooshyar Dariush | KAZEMI JAHROMI MITRA | Issue Writer Certificate

Keywords

Ibuprofen

COVID-19

NSAIDs

Mortality

Abstract

Background: No specific study has investigated the effect of non-steroidal anti inflammatory drugs (NSAIDs) and especially the effects of Ibuprofen on COVID-19, so far. Objectives: The purpose of this study was to investigate the effect of Ibuprofen on the severity of COVID-19 and Mortality caused by the disease. Methods: This study was conducted on 158 patients with COVID-19 who had consumed Ibuprofen, Gelofen, and Novafen for at least one week in the last three months. Patients were divided into three groups (mild, moderate and sever). The relationship among the severity of the disease and the history of Ibuprofen consumption, diabetes, history of cardiovascular problems, hypertension, and GFR was investigated. Also, the association between the history of Ibuprofen consumption, GFR 60 mL/min, hypertension, LDH 500 U/L, lymphocyte count 1500, and Mortality was examined. Results: Our findings showed a significant relationship between the history of Ibuprofen before COVID-19 and the severity of COVID-19, as well as the Mortality rate (P value < 0. 001, adjusted odd ratio: 2, respectively). This study also showed a significant relationship among the severity of the disease and the history of smoking, diabetes, hypertension, history of cardiovascular diseases, and GFR. In addition, a significant relationship was found among GFR 60 mL/min Mortality, diabetes, LDH 500 U/L, and lymphocyte count 1500. Conclusions: Our study showed a significant relationship between the history of the consumption of Ibuprofen and itscompounds before COVID-19andthe severity of COVID-19, as well as the Mortality rate of the patients with this disease, andaccordingly, this result can suggest health policies during the epidemic of COVID-19.

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APA: Copy

SAMIMAGHAM, HAMIDREZA, ARABI, MOHSEN, Hooshyar, Dariush, & KAZEMI JAHROMI, MITRA. (2020). The Association of Non-Steroidal Anti-Inflammatory Drugs with COVID-19 Severity and Mortality. ARCHIVES OF CLINICAL INFECTIOUS DISEASES, 15(4), 0-0. SID. https://sid.ir/paper/698689/en

Vancouver: Copy

SAMIMAGHAM HAMIDREZA, ARABI MOHSEN, Hooshyar Dariush, KAZEMI JAHROMI MITRA. The Association of Non-Steroidal Anti-Inflammatory Drugs with COVID-19 Severity and Mortality. ARCHIVES OF CLINICAL INFECTIOUS DISEASES[Internet]. 2020;15(4):0-0. Available from: https://sid.ir/paper/698689/en

IEEE: Copy

HAMIDREZA SAMIMAGHAM, MOHSEN ARABI, Dariush Hooshyar, and MITRA KAZEMI JAHROMI, “The Association of Non-Steroidal Anti-Inflammatory Drugs with COVID-19 Severity and Mortality,” ARCHIVES OF CLINICAL INFECTIOUS DISEASES, vol. 15, no. 4, pp. 0–0, 2020, [Online]. Available: https://sid.ir/paper/698689/en

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