Comparison of Antiviral Effects of Methanol and Hexane Extracts of Chelidonium Majus L. Against Acyclovir Resistant Herpes Simplex Type 1

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Haji Mohammad Ali Roshanak; PARSANIA MASOUD; AMIN GHOLAMREZA

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Journal Paper

Paper Information

Journal: Journal of Arak University Medical Sciences Year:2018 | Volume:21 | Issue:3 (132) Page(s): 42-52

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Information Journal Paper

Title

Comparison of Antiviral Effects of Methanol and Hexane Extracts of Chelidonium Majus L. Against Acyclovir Resistant Herpes Simplex Type 1

Author(s)

Haji Mohammad Ali Roshanak | PARSANIA MASOUD | AMIN GHOLAMREZA | Issue Writer Certificate

Keywords

Acyclovir-resistant Herpes simplex virusQ1

type 1Q1

Antiviral effectsQ1

Chelidonium majus L.extractsQ1

Abstract

Background and Aim: Herpes simplex virus type 1 (HSV-1) may lead to oral herpes, encephalitis and keratoconjunctivitis. Today, following the increasing of HSV-1 prevalence and drug resistance, there has been an interest in the use of natural substance. In this study, we assessed the effect of hexane and methanol extracts of Chelidonium majus L. against acyclovir-resistant HSV-1. Materials and Methods: The toxicity threshold of Chelidonium majus L. hexane and methanol extracts on HeLa cell was determined with trypan blue and MTT methods. Their direct Antiviral effects were evaluated against HSV-1. Different concentrations of extracts in different times of virus replication have been evaluated. In each stage, the viral titers were tested by TCID50 assay. Findings: The methanol extract at the concentration of 200 μ g/ml and hexane extract at the concentration of 600 μ g/ml were determined as effective minimal cytotoxic concentration on HeLa cell line. These concentrations did not have significant virucidal effects on Herpes simplex virus. The maximum Antiviral effects of methanol extract at the concentration of 200 μ g/ml was exhibited 1 and 2 hours after virus adsorption and reduced virus titer 4 logTCID50 compared to the control. Hexane extract did not have antiviral effect. Conclusion: methanol extract of chelidonium majus L. compared to hexane extract showed significant antiviral effect on acyclovir-resistant HSV-1. Further research is required to identify specific bioactive compounds of this plant in order to be used in anti-herpes drugs.

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References

ANTIVIRAL AND VIRUCIDAL ACTIVITY OF CHELIDONIUM MAJUS L. EXTRACT COMPARED WITH ACYCLOVIR AGAINST HERPES SIMPLEX VIRUS TYPE 1

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APA: Copy

Haji Mohammad Ali, Roshanak, PARSANIA, MASOUD, & AMIN, GHOLAMREZA. (2018). Comparison of Antiviral Effects of Methanol and Hexane Extracts of Chelidonium Majus L. Against Acyclovir Resistant Herpes Simplex Type 1. ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ), 21(3 (132) ), 42-52. SID. https://sid.ir/paper/69886/en

Vancouver: Copy

Haji Mohammad Ali Roshanak, PARSANIA MASOUD, AMIN GHOLAMREZA. Comparison of Antiviral Effects of Methanol and Hexane Extracts of Chelidonium Majus L. Against Acyclovir Resistant Herpes Simplex Type 1. ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ)[Internet]. 2018;21(3 (132) ):42-52. Available from: https://sid.ir/paper/69886/en

IEEE: Copy

Roshanak Haji Mohammad Ali, MASOUD PARSANIA, and GHOLAMREZA AMIN, “Comparison of Antiviral Effects of Methanol and Hexane Extracts of Chelidonium Majus L. Against Acyclovir Resistant Herpes Simplex Type 1,” ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ), vol. 21, no. 3 (132) , pp. 42–52, 2018, [Online]. Available: https://sid.ir/paper/69886/en

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