TO STUDY THE ASSOCIATION BETWEEN ACRAB AND QEP A EFFLUX PUMPS AND CIPROFLOXACIN RESISTANCE AMONG ESCHERICHIA COLI AND KLEBSIELLA PNEUMONIAE CLINICAL STRAINS

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HEIDARY MOHSEN; BAHRAMIAN AGHIL; GOUDARZI HOSSEIN; ESLAMI GITA; HASHEMI ALI; KHOSHNOOD SAEED

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Journal: ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ) Year:2016 | Volume:19 | Issue:4 (109) Page(s): 1-10

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Title

TO STUDY THE ASSOCIATION BETWEEN ACRAB AND QEP A EFFLUX PUMPS AND CIPROFLOXACIN RESISTANCE AMONG ESCHERICHIA COLI AND KLEBSIELLA PNEUMONIAE CLINICAL STRAINS

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Keywords

KLEBSIELLA PNEUMONIAEQ2

EFFLUX PUMPQ1

FLUOROQUINOLONEQ1

ANTIBIOTIC SENSITIVITYQ1

Abstract

Background: The EFFLUX PUMPs are one of the main mechanisms of resistance to antibiotics in E. coli and K. pneumoniae strains. The aim of this study is to study the association between genes coding EFFLUX PUMPs AcrAB and Qep A and ciprofloxacin resistance among E. coli and K. pneumoniae clinical strains.Materials and Methods: This study was done on 100 strains of E. coli isolated from Taleghani and Labbafinejad Hospitals and 100 strains of K. pneumoniae isolated from Taleghani and Mofid Children Hospitals. Antimicrobial susceptibility tests were performed by disk diffusion method based on CLSI guidelines. Identification of genes encoding EFFLUX PUMPs Acr AB and Qep A was done by PCR technique.Results: In this study, fosfomycin and imipenem had the best effect against E. coli clinical isolates and fosfomycin and tigecycline had the best effect against K. pneumoniae clinical isolates. PCR assay demonstrated that the prevalence of AcrA, AcrB and QepA genes among E. coli isolates were 92%, 84% and 0%, respectively and among K. pneumoniae isolates were 94%, 87% and 4%, respectively.Conclusion: The prevalence of genes encoding EFFLUX PUMPs in E. coli and K. pneumonia clinical strains, which causes resistance to FLUOROQUINOLONEs, is cause for concern. Therefore, controlling infection and preventing the spread of drug-resistant bacteria needs to manage medication carefully and identify resistant isolates.

Cites

Integron-associated Antibiotic Resistance in Clinical Isolates of Klebsiella from Karaj

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APA: Copy

HEIDARY, MOHSEN, BAHRAMIAN, AGHIL, GOUDARZI, HOSSEIN, ESLAMI, GITA, HASHEMI, ALI, & KHOSHNOOD, SAEED. (2016). TO STUDY THE ASSOCIATION BETWEEN ACRAB AND QEP A EFFLUX PUMPS AND CIPROFLOXACIN RESISTANCE AMONG ESCHERICHIA COLI AND KLEBSIELLA PNEUMONIAE CLINICAL STRAINS. ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ), 19(4 (109)), 1-10. SID. https://sid.ir/paper/69892/en

Vancouver: Copy

HEIDARY MOHSEN, BAHRAMIAN AGHIL, GOUDARZI HOSSEIN, ESLAMI GITA, HASHEMI ALI, KHOSHNOOD SAEED. TO STUDY THE ASSOCIATION BETWEEN ACRAB AND QEP A EFFLUX PUMPS AND CIPROFLOXACIN RESISTANCE AMONG ESCHERICHIA COLI AND KLEBSIELLA PNEUMONIAE CLINICAL STRAINS. ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ)[Internet]. 2016;19(4 (109)):1-10. Available from: https://sid.ir/paper/69892/en

IEEE: Copy

MOHSEN HEIDARY, AGHIL BAHRAMIAN, HOSSEIN GOUDARZI, GITA ESLAMI, ALI HASHEMI, and SAEED KHOSHNOOD, “TO STUDY THE ASSOCIATION BETWEEN ACRAB AND QEP A EFFLUX PUMPS AND CIPROFLOXACIN RESISTANCE AMONG ESCHERICHIA COLI AND KLEBSIELLA PNEUMONIAE CLINICAL STRAINS,” ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ), vol. 19, no. 4 (109), pp. 1–10, 2016, [Online]. Available: https://sid.ir/paper/69892/en

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