IRISIN RESPONSE TO TWO TYPES OF EXERCISE TRAINING IN TYPE 2 DIABETIC MALE RATS

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KHALAFI MOUSA; SHABKHIZ FATEMEH; AAZALI ALAMDARI KARIM; BAKHTIYARI AFARIN

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Journal: ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ) Year:2016 | Volume:19 | Issue:6 (111) Page(s): 37-45

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Title

IRISIN RESPONSE TO TWO TYPES OF EXERCISE TRAINING IN TYPE 2 DIABETIC MALE RATS

Author(s)

KHALAFI MOUSA | SHABKHIZ FATEMEH | AAZALI ALAMDARI KARIM | BAKHTIYARI AFARIN | Issue Writer Certificate

Keywords

HIGH INTENSITY INTERVAL TRAININGQ1

LOW INTENSITY CONTINUOUS TRAININGQ1

IRISINQ1

INSULIN RESISTANCEQ1

TYPE 2 DIABETESQ1

Abstract

Background: IRISIN is an exercise-induced myokine that is reduced with TYPE 2 DIABETES andimproves INSULIN RESISTANCE via the browning of white adipose tissues. However, IRISIN response to twotypes of exercise in patients with TYPE 2 DIABETES is unknown.Materials and Methods: In this study, 22 diabetic Wistar rats (Induced by high-fat diet andinjections Stz) were randomly assigned to 3 groups: high intensity interval exercise (HIIT), lowintensity continuous training (LICT) and control (C). Both HIIT and LICT groups trained on thetreadmill 5 sessions per week for 8 weeks. Blood samples were taken 24 hours after the last trainingsession and plasma IRISIN, insulin and glucose levels were measured. ANOVA and Tukey post hoctests were used to analyze data and the level of significance has been considered at p≤0.05.Results: Data analysis showed that plasma IRISIN levels in the HIIT group were significantlyincreased compared to the control group (p<0.05). However, there was no significant differencebetween other groups (p>0.05). Plasma glucose in both HIIT and LICT groups was significantlydecreased compared to the control group (p<0.05). But plasma insulin levels and INSULIN RESISTANCEindex were not different between groups (p>0.05).Conclusion: The results of this study showed that exercise training can increase plasma IRISINin rats with TYPE 2 DIABETES. However, these changes are partially dependent on the type of exercisetraining.

Cites

THE EFFECT OF 3 WEEKS OF CYCLING WITH AND WITHOUT VASCULAR OCCLUSION ON PLASMA CONCENTRATION OF IRISIN AND PGC-1α IN HEALTHY MEN

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APA: Copy

KHALAFI, MOUSA, SHABKHIZ, FATEMEH, AAZALI ALAMDARI, KARIM, & BAKHTIYARI, AFARIN. (2016). IRISIN RESPONSE TO TWO TYPES OF EXERCISE TRAINING IN TYPE 2 DIABETIC MALE RATS. ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ), 19(6 (111)), 37-45. SID. https://sid.ir/paper/69915/en

Vancouver: Copy

KHALAFI MOUSA, SHABKHIZ FATEMEH, AAZALI ALAMDARI KARIM, BAKHTIYARI AFARIN. IRISIN RESPONSE TO TWO TYPES OF EXERCISE TRAINING IN TYPE 2 DIABETIC MALE RATS. ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ)[Internet]. 2016;19(6 (111)):37-45. Available from: https://sid.ir/paper/69915/en

IEEE: Copy

MOUSA KHALAFI, FATEMEH SHABKHIZ, KARIM AAZALI ALAMDARI, and AFARIN BAKHTIYARI, “IRISIN RESPONSE TO TWO TYPES OF EXERCISE TRAINING IN TYPE 2 DIABETIC MALE RATS,” ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ), vol. 19, no. 6 (111), pp. 37–45, 2016, [Online]. Available: https://sid.ir/paper/69915/en

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