ANALYSIS OF Y CHROMOSOME MICRODELETIONS AND MUTATION IN EXON7 OF THE STAG3 GENE IN IRANIAN INFERTILE MEN WITH IDIOPATHIC NON- OBSTRUCTIVE AZOOSPERMIA

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POURIAMANESH SARA; KAMALIAN ZIBA; SHAFAAT PEDRAM; AMIN BIDOKHTI MONA; SALSABILI NASSER; MIRFAKHRAEI REZA

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Title

ANALYSIS OF Y CHROMOSOME MICRODELETIONS AND MUTATION IN EXON7 OF THE STAG3 GENE IN IRANIAN INFERTILE MEN WITH IDIOPATHIC NON- OBSTRUCTIVE AZOOSPERMIA

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Keywords

MICRODELETIONQ1

Y CHROMOSOMEQ1

AZOOSPERMIAQ1

MUTATIONQ2

STAG3Q1

Abstract

Background: AZOOSPERMIA is defined as the absence of sperm in the semen and is divided intwo types; obstructive and non-obstructive AZOOSPERMIA. Non-obstructive AZOOSPERMIA includeapproximately 60% of AZOOSPERMIA patients. Several genetic and environmental factors can beinvolved in the development of non-obstructive AZOOSPERMIA. Until now, several genes have beenintroduced as the causing factor of the AZOOSPERMIA that are involved in spermatogenesis and testiculardevelopment. These genes are located on Y and/or autosome chromosomes.The aim of the presentstudy was to investigate Y CHROMOSOME MICRODELETIONs and STAG3 gene MUTATIONs in Iranian maleswith non-obstructive AZOOSPERMIA.Materials and Methods: In this study, peripheral blood samples were obtained from 122 menwith idiopathic non-obstructive AZOOSPERMIA and 100 Normo-sperm men who had at least one childand DNA was extracted. Samples were investigated for the presence of Y CHROMOSOME MICRODELETIONsby Multiplex PCR. Then, existence of probable MUTATIONs in exon 7 of STAG3 gene was investigatedusing MSSCP (multi-temperature single-strand conformational polymorphism) method.Results: 13 patients (10.66%) had Y CHROMOSOME MICRODELETIONs, but none of the subjectsshowed MUTATION in exon 7 of STAG3 gene. The Y CHROMOSOME MICRODELETIONs were found in none ofthe control individuals.Conclusion: The results showed that Y CHROMOSOME MICRODELETIONs are the most importantcause of non-obstructive AZOOSPERMIA and should be considered as the main candidate for maleinfertility diagnostic tests. MUTATIONs in the STAG3 gene are not common among non-obstructiveazoospermia patients.

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APA: Copy

POURIAMANESH, SARA, KAMALIAN, ZIBA, SHAFAAT, PEDRAM, AMIN BIDOKHTI, MONA, SALSABILI, NASSER, & MIRFAKHRAEI, REZA. (2016). ANALYSIS OF Y CHROMOSOME MICRODELETIONS AND MUTATION IN EXON7 OF THE STAG3 GENE IN IRANIAN INFERTILE MEN WITH IDIOPATHIC NON- OBSTRUCTIVE AZOOSPERMIA. ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ), 19(6 (111)), 19-26. SID. https://sid.ir/paper/69916/en

Vancouver: Copy

POURIAMANESH SARA, KAMALIAN ZIBA, SHAFAAT PEDRAM, AMIN BIDOKHTI MONA, SALSABILI NASSER, MIRFAKHRAEI REZA. ANALYSIS OF Y CHROMOSOME MICRODELETIONS AND MUTATION IN EXON7 OF THE STAG3 GENE IN IRANIAN INFERTILE MEN WITH IDIOPATHIC NON- OBSTRUCTIVE AZOOSPERMIA. ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ)[Internet]. 2016;19(6 (111)):19-26. Available from: https://sid.ir/paper/69916/en

IEEE: Copy

SARA POURIAMANESH, ZIBA KAMALIAN, PEDRAM SHAFAAT, MONA AMIN BIDOKHTI, NASSER SALSABILI, and REZA MIRFAKHRAEI, “ANALYSIS OF Y CHROMOSOME MICRODELETIONS AND MUTATION IN EXON7 OF THE STAG3 GENE IN IRANIAN INFERTILE MEN WITH IDIOPATHIC NON- OBSTRUCTIVE AZOOSPERMIA,” ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ), vol. 19, no. 6 (111), pp. 19–26, 2016, [Online]. Available: https://sid.ir/paper/69916/en

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