EFFECTS OF OLIGOFRUCTOSE-ENRICHED INULIN PREBIOTIC SUPPLEMENTATION ON THE LIPID PROFILE AND INFLAMMATION IN WOMEN WITH TYPE 2 DIABETES: A RANDOMIZED CONTROLLED TRIAL

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POURGHASSEM GARGARI B.; DEHGHAN P.; MIRTAHERI E.; FAGHFOORI Z.; KARIMI P.

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Journal: Journal of Arak University Medical Sciences Year:2013 | Volume:16 | Issue:8 (77) Page(s): 0-0

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Title

EFFECTS OF OLIGOFRUCTOSE-ENRICHED INULIN PREBIOTIC SUPPLEMENTATION ON THE LIPID PROFILE AND INFLAMMATION IN WOMEN WITH TYPE 2 DIABETES: A RANDOMIZED CONTROLLED TRIAL

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Keywords

INFLAMMATIONQ2

INULINQ2

TYPE 2 DIABETESQ3

Abstract

Background: Considering the high prevalence of diabetes and developing cardiovascular diseases through dyslipidemia and INFLAMMATION in type 2 diabetic patients, the aim of the present study was to investigate the effects of oligofructose-enriched INULIN on serum lipid concentrations and INFLAMMATION in women with TYPE 2 DIABETES.Materials and Methods: In this clinical trial, 52 women with TYPE 2 DIABETES were randomly assigned to one of two groups. Experimental group (n=27) received 10g/day oligofructose-enriched INULIN and control group (n=25) received 10g/day maltodextrin (placebo) for 8 weeks. Dietary intakes, anthropometric indicies, hs-CRP and serum lipids levels were measured at the baseline and at the end of the study. Data were analyzed using SPSS software (verision11.5). Paired, independent t-test and ANCOVA were used to compare comparison of quantitative variables.Results: At the end of study, significant decrease was observed in total cholesterol levels mean (28.00 mg/dL, 14.10%), LDL-c (22.00 mg/dL, 21.70%), TC/HDL-c ratio (0.73, 20.70%) and LDLc/ HDL-c ratio (0.55, 27.50%) in oligofructose-enriched INULIN compared with the maltodextrin group (p=0.03). Changes in concentrations of triglycerides, hsCRP and high-density lipoprotein were not significant in oligofructose-enriched INULIN compared to maltodextrin group.Conclusions: Oligofructose-enriched INULIN supplementation with improving in inflammtion and lipid profile help in management of TYPE 2 DIABETES and its complications.

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APA: Copy

POURGHASSEM GARGARI, B., DEHGHAN, P., MIRTAHERI, E., FAGHFOORI, Z., & KARIMI, P.. (2013). EFFECTS OF OLIGOFRUCTOSE-ENRICHED INULIN PREBIOTIC SUPPLEMENTATION ON THE LIPID PROFILE AND INFLAMMATION IN WOMEN WITH TYPE 2 DIABETES: A RANDOMIZED CONTROLLED TRIAL. ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ), 16(8 (77)), 0-0. SID. https://sid.ir/paper/69924/en

Vancouver: Copy

POURGHASSEM GARGARI B., DEHGHAN P., MIRTAHERI E., FAGHFOORI Z., KARIMI P.. EFFECTS OF OLIGOFRUCTOSE-ENRICHED INULIN PREBIOTIC SUPPLEMENTATION ON THE LIPID PROFILE AND INFLAMMATION IN WOMEN WITH TYPE 2 DIABETES: A RANDOMIZED CONTROLLED TRIAL. ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ)[Internet]. 2013;16(8 (77)):0-0. Available from: https://sid.ir/paper/69924/en

IEEE: Copy

B. POURGHASSEM GARGARI, P. DEHGHAN, E. MIRTAHERI, Z. FAGHFOORI, and P. KARIMI, “EFFECTS OF OLIGOFRUCTOSE-ENRICHED INULIN PREBIOTIC SUPPLEMENTATION ON THE LIPID PROFILE AND INFLAMMATION IN WOMEN WITH TYPE 2 DIABETES: A RANDOMIZED CONTROLLED TRIAL,” ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ), vol. 16, no. 8 (77), pp. 0–0, 2013, [Online]. Available: https://sid.ir/paper/69924/en

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