Reduction of Bisphenol A-induced Male Reproductive Toxicity by Bromelain in Mice

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

KHAZAEEL KAVEH; Atashfaraz Ammar; Davoudi Zhara; Jamshidian Javad; ERFANI MAJD NAEEM; Mohammadi Ghodratollah

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Journal of Kermanshah University of Medical Sciences Year:2021 | Volume:25 | Issue:3 Page(s): 0-0

Download Full-Text

View:

Download:

Cites:

Information Journal Paper

Title

Reduction of Bisphenol A-induced Male Reproductive Toxicity by Bromelain in Mice

Author(s)

Keywords

Bisphenol A

Bromelain

Histomorphometry

Sperm

Testis

Abstract

Background: Bisphenol A (BPA) is an endocrine-disrupting agent with a weak estrogenic effect. BPA causes testicular damage by reducing the activity of antioxidant enzymes. Bromelain (BROM) is a natural compound derived from pineapple, which is widely used as a dietary supplement with antioxidant properties. Objectives: The present study aimed to investigate the possible therapeutic effects of BROM on the testicular damage induced by BPA administration. Methods: This study was conducted on 40 adult male mice, which were divided into four groups of control (daily treatment with olive oil), BPA (600 mg/kg), BROM (70 mg/kg), and BPA + BROM. The treatments were administered orally for 35 consecutive days. Following that, the animals were euthanized by cervical dislocation, their testes were dissected, and morphometric evaluations (length, width, and thickness of Testis) were performed. The epididymal tail was cut to release the Sperms for Sperm parameter assessment (count and motility). Afterwards, the testes were fixed in buffered formalin for histological examinations (number, diameter, and wall thickness of seminiferous tubules and the counts of Spermatogenic, Sertoli, and Leydig cells). Results: All the indices of testicular morphology decreased significantly (P < 0. 05) following BPA administration compared to the controls. In addition, the Sperm parameters and Leydig and Sertoli cell counts indicated significant decremental effects on the animals administered with BPA compared to the controls (P < 0. 05). After the administration of BROM in the BPA + BROM group, all the testicular morphometric indices increased significantly (P < 0. 05) compared to the animals administered with BPA alone. These indices were the morphometric values of the testes, Sperm parameters, cell counts, and seminiferous morphometric properties. Conclusions: According to the results, BROM could reduce the debilitative effects of BPA on the testes of the mice and protect the reproductive health of the animals against BPA-induced toxicity.

Cites

No record.

References

Bromelain inhibits the ability of colorectal cancer cells to proliferate via activation of ROS production and autophagy

Cite

APA: Copy

KHAZAEEL, KAVEH, Atashfaraz, Ammar, Davoudi, Zhara, Jamshidian, Javad, ERFANI MAJD, NAEEM, & Mohammadi, Ghodratollah. (2021). Reduction of Bisphenol A-induced Male Reproductive Toxicity by Bromelain in Mice. JOURNAL OF KERMANSHAH UNIVERSITY OF MEDICAL SCIENCES (BEHBOOD), 25(3), 0-0. SID. https://sid.ir/paper/699384/en

Vancouver: Copy

KHAZAEEL KAVEH, Atashfaraz Ammar, Davoudi Zhara, Jamshidian Javad, ERFANI MAJD NAEEM, Mohammadi Ghodratollah. Reduction of Bisphenol A-induced Male Reproductive Toxicity by Bromelain in Mice. JOURNAL OF KERMANSHAH UNIVERSITY OF MEDICAL SCIENCES (BEHBOOD)[Internet]. 2021;25(3):0-0. Available from: https://sid.ir/paper/699384/en

IEEE: Copy

KAVEH KHAZAEEL, Ammar Atashfaraz, Zhara Davoudi, Javad Jamshidian, NAEEM ERFANI MAJD, and Ghodratollah Mohammadi, “Reduction of Bisphenol A-induced Male Reproductive Toxicity by Bromelain in Mice,” JOURNAL OF KERMANSHAH UNIVERSITY OF MEDICAL SCIENCES (BEHBOOD), vol. 25, no. 3, pp. 0–0, 2021, [Online]. Available: https://sid.ir/paper/699384/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops