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1

Information Journal Paper

Title

Evaluation of the central and peripheral effects of doxepin on carrageenan-induced inflammatory paw edema in rat

Pages

  337-345

Abstract

 The Anti-inflammatory effects of anti-depressants have been demonstrated recently. Doxepin, a tricyclic antidepressant drug (TCA), has some special properties in comparison with the other members of its family. It has some H1, H2, alpha-1 adrenergic and muscarinic receptor blocking effects. It revealed also anti-nociceptive and relatively potent sedative effects. This study was aimed to evaluate its possible antiinflammatory effect in a well-established animal model. Male Wistar rats weighing 200-250 g were used in Carrageenan-induced inflammatory paw edema model. The test and control drugs were injected by intraperitoneal (i. p. ) and intracerebral (i. c. v. ) routes. The Anti-inflammatory activity of Doxepin (15, 30 and 60 mg/kg, i. p. and 50 and 100 μ g/rat, i. c. v. ) and the reference drug, dexamethasone (2 mg/kg, i. p. ) were evaluated by determination and comparison of some involved biological markers including the paw volume, cytokine levels (interleukin 6 (IL-6), IL-1β , tumor necrosis factor α (TNFα )), myeloperoxidase (MPO) activity and histopathological parameters. All i. p. doses of Doxepin showed significant Anti-inflammatory effect. It also significantly reduced MPO activity and cytokine levels and improved histopathologic parameters of Carrageenan-injected paw tissues. I. c. v. administration of the drug did not show any significant reduction of Carrageenan-induced paw edema. Although the exact mechanism of the Anti-inflammatory effect of Doxepin is not clear, it seems that reduced leukocyte migration and pro-inflammatory Cytokines play important role in its Anti-inflammatory effect. Also central sites are not involved in the Anti-inflammatory effect of the drug.

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    • Cite

    APA: Copy

    ZABIHI, MOHSEN, HAJHASHEMI, VALIOLLAH, MINAIYAN, MOHSEN, & TALEBI, ARDESHIR. (2017). Evaluation of the central and peripheral effects of doxepin on carrageenan-induced inflammatory paw edema in rat. RESEARCH IN PHARMACEUTICAL SCIENCES (RPS), 12(4), 337-345. SID. https://sid.ir/paper/699999/en

    Vancouver: Copy

    ZABIHI MOHSEN, HAJHASHEMI VALIOLLAH, MINAIYAN MOHSEN, TALEBI ARDESHIR. Evaluation of the central and peripheral effects of doxepin on carrageenan-induced inflammatory paw edema in rat. RESEARCH IN PHARMACEUTICAL SCIENCES (RPS)[Internet]. 2017;12(4):337-345. Available from: https://sid.ir/paper/699999/en

    IEEE: Copy

    MOHSEN ZABIHI, VALIOLLAH HAJHASHEMI, MOHSEN MINAIYAN, and ARDESHIR TALEBI, “Evaluation of the central and peripheral effects of doxepin on carrageenan-induced inflammatory paw edema in rat,” RESEARCH IN PHARMACEUTICAL SCIENCES (RPS), vol. 12, no. 4, pp. 337–345, 2017, [Online]. Available: https://sid.ir/paper/699999/en

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