THE EFFECT OF PROGESTERONE ON LIPID PEROXIDATION AND IN RAT ALZHEIMER MODEL BY LOCAL INJECTION OF STREPTOZOTOCIN

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

MOZAFARI MARYAM; HATAMI HOMEIRA; BANAN KHOJASTEH SEYED MAHDI; DEHGAN GOLAMREZA

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Journal of Shahid Sadoughi University of Medical Sciences Year:2016 | Volume:24 | Issue:7 Page(s): 0-0

Download Full-Text

View:

235

Download:

Cites:

Information Journal Paper

Title

THE EFFECT OF PROGESTERONE ON LIPID PEROXIDATION AND IN RAT ALZHEIMER MODEL BY LOCAL INJECTION OF STREPTOZOTOCIN

Author(s)

MOZAFARI MARYAM | HATAMI HOMEIRA | BANAN KHOJASTEH SEYED MAHDI | DEHGAN GOLAMREZA | Issue Writer Certificate

Keywords

ALZHEIMER

SPATIAL MEMORY

PROGESTERONE

PEROXIDATION

Abstract

Introduction: ALZHEIMER’s disease is one of the most prevalent brain neurodegenerative diseases and the most common cognitive deficits are memory dysfunction and spatial perception impairment. PROGESTERONE has a neorostroid action in hippocampal neurogenesis, synaptic stability and spatial learning and memory and has antioxidant effect. Since oxidative stress is involved in the pathogenesis of ALZHEIMER's disease, and conflicting results were reported about the effects of PROGESTERONE on therefore in ALZHEIMER’s, the present study investigated the effect of microinjection of three doses of PROGESTERONE on the process of SPATIAL MEMORY and lipid PEROXIDATION and total PEROXIDATION in the hippocampus in the experimental model of AD.Methods: 42 adult male Wistar rats weighting 250±50 g were randomly divided into six main groups (n=7): control group, sham group, ALZHEIMER’s model (intracerebroventricular injection of streptozotocin), ALZHEIMER model+progesterone (0.5, 1.5, 2µg/kg). 2 weeks after injection of streptozotocin (3 mg/kg), ALZHEIMER's was induced then PROGESTERONE injected in different doses. After termination of behavioral testing days, the hippocampus was removed to measure the levels of oxidative stress parameter to measure levels of oxidative stress parameters. Statistical analysis was performed using analysis of variance (ANOVA).Results: Results showed that intraventricular injection of STZ decreased SPATIAL MEMORY in comparison to control group (P<0.001). Administration PROGESTERONE significantly improved SPATIAL MEMORY in experimental models of ALZHEIMER's rats (P<0.001). MDA and SOD in all doses of PROGESTERONE showed a significant reduction compared to the AD animals (P<0.001).Conclusion: PROGESTERONE can prevent a decrease in spatial learning and memory by reducing oxidative stress in the hippocampus of rats with ALZHEIMER's.

Cites

No record.

References

No record.

Cite

APA: Copy

MOZAFARI, MARYAM, HATAMI, HOMEIRA, BANAN KHOJASTEH, SEYED MAHDI, & DEHGAN, GOLAMREZA. (2016). THE EFFECT OF PROGESTERONE ON LIPID PEROXIDATION AND IN RAT ALZHEIMER MODEL BY LOCAL INJECTION OF STREPTOZOTOCIN. JOURNAL OF SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES, 24(7), 0-0. SID. https://sid.ir/paper/700254/en

Vancouver: Copy

MOZAFARI MARYAM, HATAMI HOMEIRA, BANAN KHOJASTEH SEYED MAHDI, DEHGAN GOLAMREZA. THE EFFECT OF PROGESTERONE ON LIPID PEROXIDATION AND IN RAT ALZHEIMER MODEL BY LOCAL INJECTION OF STREPTOZOTOCIN. JOURNAL OF SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2016;24(7):0-0. Available from: https://sid.ir/paper/700254/en

IEEE: Copy

MARYAM MOZAFARI, HOMEIRA HATAMI, SEYED MAHDI BANAN KHOJASTEH, and GOLAMREZA DEHGAN, “THE EFFECT OF PROGESTERONE ON LIPID PEROXIDATION AND IN RAT ALZHEIMER MODEL BY LOCAL INJECTION OF STREPTOZOTOCIN,” JOURNAL OF SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES, vol. 24, no. 7, pp. 0–0, 2016, [Online]. Available: https://sid.ir/paper/700254/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops