BIOCHEMICAL AND MOLECULAR EVIDENCES ON THE PROTECTION BY MAGNESIUM OXIDE NANOPARTICLES OF CHLORPYRIFOS-INDUCED APOPTOSIS IN HUMAN LYMPHOCYTES

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Heydari Vida; NAVAEI NIGJEH MONA; RAHIMIFARD MAHBAN; MOHAMMADIRAD AZADEH; BAEERI MARYAM; ABDOLLAHI MOHAMMAD

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Journal: JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS) Year:2015 | Volume:20 | Issue:11 Page(s): 0-0

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Title

BIOCHEMICAL AND MOLECULAR EVIDENCES ON THE PROTECTION BY MAGNESIUM OXIDE NANOPARTICLES OF CHLORPYRIFOS-INDUCED APOPTOSIS IN HUMAN LYMPHOCYTES

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Keywords

ACETYLCHOLINESTERASE (ACHE)

ANTIAPOPTOTIC

ANTIOXIDANT

CHLORPYRIFOS (CP)

HUMAN LYMPHOCYTES

MAGNESIUM OXIDE NANOPARTICLE (MGO NP)

ORGANOPHOSPHATE (OP)

OXIDATIVE STRESS

Abstract

Background: Chlorpyrifos (CP) is one of the most widely used organophosphate (OP) insecticides in agricultural and residential pestcontrol with its attendant adverse health effect. In the present study, it is proposed to investigate the possible modulatory role of magnesiumoxide nanoparticles (MgO NPs) against CP-induced toxicity in HUMAN LYMPHOCYTES and determine the mechanisms lying behind thisprotection by viability and biochemical assays. Materials and Methods: Isolated lymphocytes were exposed to 12 mg/mL CP either aloneor in combination with different concentrations of MgO NPs (0.1 mg/mL, 1 mg/mL, 10 mg/mL, and 100 mg/mL). After a 3-day incubation, the viability and OXIDATIVE STRESS markers including cellular mitochondrial activity, caspase-3 and -9 activities, total ANTIOXIDANT power, lipidperoxidation, and myeloperoxidase (MPO) activity were measured. Also, the levels of tumor necrosis factor-a (TNF-a) as inflammatoryindex, along with acetylcholinesterase (AChE) activity were measured. Statistical differences were determined using one-way analysis ofvariance (ANOVA) and Dunnett’s multiple comparison tests.Results: It is indicated that CP-exposed lymphocytes treated with MgONPs resulted in a substantial reduction in the pace of mortality as well as the stages of OXIDATIVE STRESS in a dose-dependent manner. Also, MgO NPs (100 mg/mL) meaningfully restored CP-induced increase of TNF-a (P<0.001) and decrease of AChE activity (P<0.001) andwere capable of preventing CP-treated HUMAN LYMPHOCYTES from apoptosis (P<0.001).Conclusion: Our results demonstrate that MgONPs in approximate 100 nm diameter not only make cells resistant to the toxic properties of CP but also attenuate toxic effects of CP, which is demonstrating the potential of MgO NPs to be applied in future immune deficiency therapeutic strategies.

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APA: Copy

Heydari, Vida, NAVAEI NIGJEH, MONA, RAHIMIFARD, MAHBAN, MOHAMMADIRAD, AZADEH, BAEERI, MARYAM, & ABDOLLAHI, MOHAMMAD. (2015). BIOCHEMICAL AND MOLECULAR EVIDENCES ON THE PROTECTION BY MAGNESIUM OXIDE NANOPARTICLES OF CHLORPYRIFOS-INDUCED APOPTOSIS IN HUMAN LYMPHOCYTES. JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS), 20(11), 0-0. SID. https://sid.ir/paper/700255/en

Vancouver: Copy

Heydari Vida, NAVAEI NIGJEH MONA, RAHIMIFARD MAHBAN, MOHAMMADIRAD AZADEH, BAEERI MARYAM, ABDOLLAHI MOHAMMAD. BIOCHEMICAL AND MOLECULAR EVIDENCES ON THE PROTECTION BY MAGNESIUM OXIDE NANOPARTICLES OF CHLORPYRIFOS-INDUCED APOPTOSIS IN HUMAN LYMPHOCYTES. JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS)[Internet]. 2015;20(11):0-0. Available from: https://sid.ir/paper/700255/en

IEEE: Copy

Vida Heydari, MONA NAVAEI NIGJEH, MAHBAN RAHIMIFARD, AZADEH MOHAMMADIRAD, MARYAM BAEERI, and MOHAMMAD ABDOLLAHI, “BIOCHEMICAL AND MOLECULAR EVIDENCES ON THE PROTECTION BY MAGNESIUM OXIDE NANOPARTICLES OF CHLORPYRIFOS-INDUCED APOPTOSIS IN HUMAN LYMPHOCYTES,” JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS), vol. 20, no. 11, pp. 0–0, 2015, [Online]. Available: https://sid.ir/paper/700255/en

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