FREQUENCY VAT1 AND FIM C GENES IN ISOLATES OF ESCHERICHIA COLI TISSUE OF PATIENTS WITH COLORECTAL CANCER AND INFLAMMATORY BOWEL DISEASE LARGE IRANIAN POPULATION

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SALIGHE ATIEH; Zargar Mohsen; MOHAMMAD GANJI SHAHLA

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Journal: NEW CELLULAR & MOLECULAR BIOTECHNOLOGY JOURNAL Year:2016 | Volume:6 | Issue:24 Page(s): 101-109

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Title

FREQUENCY VAT1 AND FIM C GENES IN ISOLATES OF ESCHERICHIA COLI TISSUE OF PATIENTS WITH COLORECTAL CANCER AND INFLAMMATORY BOWEL DISEASE LARGE IRANIAN POPULATION

Author(s)

SALIGHE ATIEH | Zargar Mohsen | MOHAMMAD GANJI SHAHLA | Issue Writer Certificate

Keywords

COLORECTAL CANCER

INFLAMMATORY BOWEL DISEASE

E. COLI

VIRULENCE GENES

VAT 1

FIM C

Abstract

Aim and Background: COLORECTAL CANCER is the third most common cancer after lung cancer, stomach and liver cancer in the world. Studies have shown that patients with inflammatory disease of the large intestine are at high risk of developing COLORECTAL CANCER are located. Several factors make INFLAMMATORY BOWEL DISEASE and COLORECTAL CANCER is one of the factors involved, bacteria and toxins derived from them. Research shows that some strains of E. COLI can be induced to increase the mutation rate that was established in 2010 by Cuvas-Romas and colleagues. fimC and vat1 VIRULENCE GENES in these organisms play an important role in bacteria pathogenicity. This study is to compare the VIRULENCE GENES in E.coli strains isolated from samples biopsy patients’ INFLAMMATORY BOWEL DISEASE and COLORECTAL CANCER, intestinal tissue was performed.Materialsand Methods: 38 biopsies were obtained from intestinal tissue and E.coli bacteria in microbial and biochemical method was identified and isolated. After DNA extraction, strains for VIRULENCE GENES VAT 1, FIM C using polymerase chain reaction (PCR), were evaluated.Results: Molecular analysis showed a significant difference between the groups studied the gene VAT 1 (p=0.0245) and 42.8% of positive samples were for this gene in normal groups, 87.5% with INFLAMMATORY BOWEL DISEASE87.5 % of patients with COLORECTAL CANCER were reported. But there is no significant difference between the groups in terms of FIM C gene (P=0.201). And 71.4% of positive samples for this gene in normal groups’ and 93.7% in patients with INFLAMMATORY BOWEL DISEASE73.3 % of patients with COLORECTAL CANCER were reported.Conclusion: The results, to confirm the good relationship between VIRULENCE GENES studied induced inflammation and proliferation by inducing mutation rate.

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APA: Copy

SALIGHE, ATIEH, Zargar, Mohsen, & MOHAMMAD GANJI, SHAHLA. (2016). FREQUENCY VAT1 AND FIM C GENES IN ISOLATES OF ESCHERICHIA COLI TISSUE OF PATIENTS WITH COLORECTAL CANCER AND INFLAMMATORY BOWEL DISEASE LARGE IRANIAN POPULATION. NEW CELLULAR & MOLECULAR BIOTECHNOLOGY JOURNAL, 6(24), 101-109. SID. https://sid.ir/paper/700356/en

Vancouver: Copy

SALIGHE ATIEH, Zargar Mohsen, MOHAMMAD GANJI SHAHLA. FREQUENCY VAT1 AND FIM C GENES IN ISOLATES OF ESCHERICHIA COLI TISSUE OF PATIENTS WITH COLORECTAL CANCER AND INFLAMMATORY BOWEL DISEASE LARGE IRANIAN POPULATION. NEW CELLULAR & MOLECULAR BIOTECHNOLOGY JOURNAL[Internet]. 2016;6(24):101-109. Available from: https://sid.ir/paper/700356/en

IEEE: Copy

ATIEH SALIGHE, Mohsen Zargar, and SHAHLA MOHAMMAD GANJI, “FREQUENCY VAT1 AND FIM C GENES IN ISOLATES OF ESCHERICHIA COLI TISSUE OF PATIENTS WITH COLORECTAL CANCER AND INFLAMMATORY BOWEL DISEASE LARGE IRANIAN POPULATION,” NEW CELLULAR & MOLECULAR BIOTECHNOLOGY JOURNAL, vol. 6, no. 24, pp. 101–109, 2016, [Online]. Available: https://sid.ir/paper/700356/en

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