Protective Effect of Swimming and Genistein on the Expression of microRNA 132, Insulin Growth Factor 1, and Brain-derived Neurotrophic Factor Genes, as well as Spatial Memory, in the Hippocampus of Diabetic Ovariectomized Rats

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

BABRI SHIRIN; HABIBI PARISA; NOURI FATEMEH; KHAZAEI MEHDI; Nayebi Rad Sepehr; Javani Gonja

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Avicenna Journal of Neuropsychophysiology Year:2021 | Volume:8 | Issue:4 Page(s): 178-185

Download Full-Text

View:

Download:

Cites:

Information Journal Paper

Title

Protective Effect of Swimming and Genistein on the Expression of microRNA 132, Insulin Growth Factor 1, and Brain-derived Neurotrophic Factor Genes, as well as Spatial Memory, in the Hippocampus of Diabetic Ovariectomized Rats

Author(s)

Keywords

Diabetes

Genistein

Ovariectomy

Spatial memory

Swimming

Abstract

Background and Objective: The present study aimed to assess the effects of the combined use of exercise and Genistein on the hippocampal expression of microRNA-132, IGF-1, and BDNF in type 2 diabetic ovariectomized rats. Materials and Methods: Wistar female rats in the weight range of 180-220 gr (n=10) were assigned to six groups: sham, Ovariectomy, ovariectomized diabetic, ovariectomized diabetic treated with Genistein for eight weeks, diabetic ovariectomized treated with Swimming for eight weeks, and a group that was treated with both Genistein and Swimming for eight weeks. The effect of those treatments was assessed by the determination of microRNA-132, insulin growth factor 1 (IGF-1), and brain-derived neurotrophic factor (BDNF) expression levels within the hippocampus. These genes were evaluated by real-time-polymerase chain reaction (RT-PCR) and Spatial memory was assessed by the Morris water maze. Results: Ovariectomy demonstrated a decrease in the expression of microRNA-132, IGF-1, and BDNF in the hippocampus, as well as Spatial memory, in diabetic ovariectomized rats, which showed a greater reduction in the expression of those genes in rats (P<0. 05). Nevertheless, Genistein administration, Swimming training, and a combination of them significantly up-regulated microRNA132, BDNF, and IGF-1 expression, as well as Spatial memory (P<0. 05). Conclusions: As evidenced by the obtained results, the combined use of Genistein and Swimming could prevent estrogen deficiency effects in the hippocampus of ovariectomized diabetic rats.

Cites

No record.

References

No record.

Cite

APA: Copy

BABRI, SHIRIN, HABIBI, PARISA, NOURI, FATEMEH, KHAZAEI, MEHDI, Nayebi Rad, Sepehr, & Javani, Gonja. (2021). Protective Effect of Swimming and Genistein on the Expression of microRNA 132, Insulin Growth Factor 1, and Brain-derived Neurotrophic Factor Genes, as well as Spatial Memory, in the Hippocampus of Diabetic Ovariectomized Rats. AVICENNA JOURNAL OF NEURO PSYCHO PHYSIOLOGY, 8(4), 178-185. SID. https://sid.ir/paper/700538/en

Vancouver: Copy

BABRI SHIRIN, HABIBI PARISA, NOURI FATEMEH, KHAZAEI MEHDI, Nayebi Rad Sepehr, Javani Gonja. Protective Effect of Swimming and Genistein on the Expression of microRNA 132, Insulin Growth Factor 1, and Brain-derived Neurotrophic Factor Genes, as well as Spatial Memory, in the Hippocampus of Diabetic Ovariectomized Rats. AVICENNA JOURNAL OF NEURO PSYCHO PHYSIOLOGY[Internet]. 2021;8(4):178-185. Available from: https://sid.ir/paper/700538/en

IEEE: Copy

SHIRIN BABRI, PARISA HABIBI, FATEMEH NOURI, MEHDI KHAZAEI, Sepehr Nayebi Rad, and Gonja Javani, “Protective Effect of Swimming and Genistein on the Expression of microRNA 132, Insulin Growth Factor 1, and Brain-derived Neurotrophic Factor Genes, as well as Spatial Memory, in the Hippocampus of Diabetic Ovariectomized Rats,” AVICENNA JOURNAL OF NEURO PSYCHO PHYSIOLOGY, vol. 8, no. 4, pp. 178–185, 2021, [Online]. Available: https://sid.ir/paper/700538/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops