COMPARISON OF SERUM MYOCARDIAL BIOMARKERS FOLLOWING TWO DIFFERENT METHODS OF VENOAORTIC CONNECTION IN CORONARY ARTERY BYPASS GRAFTING: A RANDOMIZED CLINICAL TRIAL

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JELODAR GHOLAMALI; ZARRABI KHALIL; NAZIFI SAEED; AZIMIFAR AZIMEH

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Journal: Zahedan Journal of Research in Medical Sciences Year:2017 | Volume:19 | Issue:7 Page(s): 0-0

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Title

COMPARISON OF SERUM MYOCARDIAL BIOMARKERS FOLLOWING TWO DIFFERENT METHODS OF VENOAORTIC CONNECTION IN CORONARY ARTERY BYPASS GRAFTING: A RANDOMIZED CLINICAL TRIAL

Author(s)

JELODAR GHOLAMALI | ZARRABI KHALIL | NAZIFI SAEED | AZIMIFAR AZIMEH | Issue Writer Certificate

Keywords

MYOCARDIAL PROTECTION

ISCHEMIA-REPERFUSION

CORONARY BYPASS

BIOMARKERS

Abstract

Background: Myocardium will expose to excessive ischemia and reperfusion during post-cardiac surgery, hence the aim of this study was to investigate the cardio protective effect of sequential partial aortic side biting technique for proximal veno-aortic anastomosis constructions in patients undergoing coronary artery bypass grafting (CABG).Methods: In this randomized clinical trial study, 60 consecutive patients who were diagnosed to suffering from triple vessel coronary artery diseases were selected. CABG patients were assigned randomly into two groups; the first group received sooner and gradual myocardial reperfusion one-by-one top end venous anastomosis to the aorta (sequential aortic side biting technique) (n= 30) and the second group undergo proximal anastomoses constructed during a single period of aortic side biting (single aortic side biting technique) (n=30). The serum levels of myocardial damage BIOMARKERS including creatine phosphokinase-MB (CPK-MB), Troponin I, glutathione peroxidase (GPX), superoxide dismutase (SOD), malondialdehyde (MDA) and catalase (CAT) were measured preoperatively, postoperatively and 24 h after operation. Independent t- tests was used to compare results between groups.Results: The level of all myocardial BIOMARKERS increased after the operation. Those in study group had significantly lower levels of troponin I (P<0.001), CPK-MB (P=0.001), GPX (P=0.007), SOD (P=0.005), and CAT (P=0.015), 24h after the operation when compared to control group. Only the serum level of CPK-MB was significantly lower in study group after the operation (P=0.029) while the other markers were comparable.Conclusions: Sequential partial occluding aortic side biting technique associated with less myocardial damage and ischemia reperfusion injury compared to conventional single method in patients undergoing elective coronary grafting.

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APA: Copy

JELODAR, GHOLAMALI, ZARRABI, KHALIL, NAZIFI, SAEED, & AZIMIFAR, AZIMEH. (2017). COMPARISON OF SERUM MYOCARDIAL BIOMARKERS FOLLOWING TWO DIFFERENT METHODS OF VENOAORTIC CONNECTION IN CORONARY ARTERY BYPASS GRAFTING: A RANDOMIZED CLINICAL TRIAL. ZAHEDAN JOURNAL OF RESEARCH IN MEDICAL SCIENCES (TABIB-E-SHARGH), 19(7), 0-0. SID. https://sid.ir/paper/701439/en

Vancouver: Copy

JELODAR GHOLAMALI, ZARRABI KHALIL, NAZIFI SAEED, AZIMIFAR AZIMEH. COMPARISON OF SERUM MYOCARDIAL BIOMARKERS FOLLOWING TWO DIFFERENT METHODS OF VENOAORTIC CONNECTION IN CORONARY ARTERY BYPASS GRAFTING: A RANDOMIZED CLINICAL TRIAL. ZAHEDAN JOURNAL OF RESEARCH IN MEDICAL SCIENCES (TABIB-E-SHARGH)[Internet]. 2017;19(7):0-0. Available from: https://sid.ir/paper/701439/en

IEEE: Copy

GHOLAMALI JELODAR, KHALIL ZARRABI, SAEED NAZIFI, and AZIMEH AZIMIFAR, “COMPARISON OF SERUM MYOCARDIAL BIOMARKERS FOLLOWING TWO DIFFERENT METHODS OF VENOAORTIC CONNECTION IN CORONARY ARTERY BYPASS GRAFTING: A RANDOMIZED CLINICAL TRIAL,” ZAHEDAN JOURNAL OF RESEARCH IN MEDICAL SCIENCES (TABIB-E-SHARGH), vol. 19, no. 7, pp. 0–0, 2017, [Online]. Available: https://sid.ir/paper/701439/en

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