SERUM VASCULAR ENDOTHELIAL GROWTH FACTOR IN IRANIAN PATIENTS WITH MODERATE-SEVERE PSORIASIS BEFORE AND AFTER TREATMENT: A PASI-75 RESPONSE AS A PRACTICAL TREATMENT GOAL

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

SHAHIDI DADRAS MOHAMMAD; ABDOLLAHIMAJD FAHIMEH; YOUNESPOUR SHIMA; NIKVAR MOHAMMAD

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: IRANIAN JOURNAL OF DERMATOLOGY Year:2016 | Volume:19 | Issue:4 Page(s): 119-124

Download Full-Text

View:

346

Download:

167

Cites:

Information Journal Paper

Title

SERUM VASCULAR ENDOTHELIAL GROWTH FACTOR IN IRANIAN PATIENTS WITH MODERATE-SEVERE PSORIASIS BEFORE AND AFTER TREATMENT: A PASI-75 RESPONSE AS A PRACTICAL TREATMENT GOAL

Author(s)

SHAHIDI DADRAS MOHAMMAD | ABDOLLAHIMAJD FAHIMEH | YOUNESPOUR SHIMA | NIKVAR MOHAMMAD | Issue Writer Certificate

Keywords

SERUM VASCULAR ENDOTHELIAL GROWTH FACTOR

PASI 75 RESPONSE

PSORIASIS

TREATMENT

Abstract

Background: Psoriasis is a chronic disease with multiple biochemical and vascular abnormalities. Several studies have evaluated circulating levels of vascular endothelial growth factor (VEGF) in psoriasis, but none of them evaluated it after reaching a PASI-75 response, as a practical treatment goal. The aim of this study was to evaluate serum levels of VEGF in moderate to severe psoriatic patients before and after treatment compared with healthy controls.Methods: This study was approved by the Ethics Committee of Shahid Beheshti University of Medical Sciences. Fifty-eight patients with moderate- severe psoriasis and 60 age-and gender-matched healthy controls were recruited to this study. Serum VEGF levels (pg/ml) of both groups were measured. We used Psoriasis Area and Severity Index (PASI) scoring to assess disease activity in patients. According to the disease severity, the patients received proper treatment. When they reached a PASI-75 response, serum VEGF levels were measured once more.Results: In our study, the median serum VEGF level was significantly higher in psoriatic patients (before and after treatment) as compared to healthy controls. Moreover, patients showed a significant reduction in their serum VEGF levels after reaching PASI-75. The median time of therapeutic effect (reaching a PASI-75 response) was four months. Furthermore, our study showed a significant correlation between the serum VEGF level and age, BMI, PASI, and disease duration (P<0.05).Conclusion: A PASI-75 response is believed to be a non-invasive assessment tool for evaluation of the treatment response. Using the PASI-75 response for evaluation or prediction of the reduction of VEGF levels could provide further clinical benefits.

Multimedia

No record.

Cites

No record.

References

No record.

Cite

APA: Copy

SHAHIDI DADRAS, MOHAMMAD, ABDOLLAHIMAJD, FAHIMEH, YOUNESPOUR, SHIMA, & NIKVAR, MOHAMMAD. (2016). SERUM VASCULAR ENDOTHELIAL GROWTH FACTOR IN IRANIAN PATIENTS WITH MODERATE-SEVERE PSORIASIS BEFORE AND AFTER TREATMENT: A PASI-75 RESPONSE AS A PRACTICAL TREATMENT GOAL. IRANIAN JOURNAL OF DERMATOLOGY, 19(4), 119-124. SID. https://sid.ir/paper/701505/en

Vancouver: Copy

SHAHIDI DADRAS MOHAMMAD, ABDOLLAHIMAJD FAHIMEH, YOUNESPOUR SHIMA, NIKVAR MOHAMMAD. SERUM VASCULAR ENDOTHELIAL GROWTH FACTOR IN IRANIAN PATIENTS WITH MODERATE-SEVERE PSORIASIS BEFORE AND AFTER TREATMENT: A PASI-75 RESPONSE AS A PRACTICAL TREATMENT GOAL. IRANIAN JOURNAL OF DERMATOLOGY[Internet]. 2016;19(4):119-124. Available from: https://sid.ir/paper/701505/en

IEEE: Copy

MOHAMMAD SHAHIDI DADRAS, FAHIMEH ABDOLLAHIMAJD, SHIMA YOUNESPOUR, and MOHAMMAD NIKVAR, “SERUM VASCULAR ENDOTHELIAL GROWTH FACTOR IN IRANIAN PATIENTS WITH MODERATE-SEVERE PSORIASIS BEFORE AND AFTER TREATMENT: A PASI-75 RESPONSE AS A PRACTICAL TREATMENT GOAL,” IRANIAN JOURNAL OF DERMATOLOGY, vol. 19, no. 4, pp. 119–124, 2016, [Online]. Available: https://sid.ir/paper/701505/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops