Antioxidative Effects of Nanocurcumin and Curcumin Against Aluminum Phosphide-induced Serum Oxidative Stress

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Mohammadi Pasand Somayyeh; RANJBAR AKRAM; KHEIRIPOUR NEJAT; GHASEMI HASSAN; Rafieemehr Hassan

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Journal Paper

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Journal: Avicenna Journal of Medical Biochemistry Year:2020 | Volume:8 | Issue:2 Page(s): 53-57

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Title

Antioxidative Effects of Nanocurcumin and Curcumin Against Aluminum Phosphide-induced Serum Oxidative Stress

Author(s)

Keywords

Nanocurcumin

Curcumin

Aluminum Phosphide

Serum

Abstract

Objectives: Aluminum Phosphide (AIP) is the commonly used pesticide in agriculture, which induces oxidative stress in almost all major body systems and organs. The aim of this study was to evaluate the efficacy of Curcumin/fa?page=1&sort=1&ftyp=all&fgrp=all&fyrs=all" target="_blank">NanoCurcumin and Curcumin on Serum oxidative stress level in subacute toxicity with AIP. Materials and Methods: In this study 36 male Wistar rats (220-250 g) were randomly divided into six groups. Control (C) receiving normal saline; group AIPreceiving AIP (2 mg/kg daily); group Cur receiving Curcumin (100 mg/kg daily); group Nano-cur receiving Curcumin/fa?page=1&sort=1&ftyp=all&fgrp=all&fyrs=all" target="_blank">NanoCurcumin (100 mg/kg daily); group AIP+ Cur receiving AIP (2 mg/kg daily) and Curcumin (100 mg/kg daily); and group AIP and Nano-cur receiving AIP (2 mg/kg daily) and Curcumin/fa?page=1&sort=1&ftyp=all&fgrp=all&fyrs=all" target="_blank">NanoCurcumin (100 mg/kg daily). Serum total antioxidant capacity (TAC), lipid peroxidation (LPO), total thiol groups (TTG), and catalase (CAT) activity were measured. Results: AIP administration led to a significant increase in LPO, and decreased the CAT activity, TAC, and TTG compared to the control group (P < 0. 05). Curcumin and Curcumin/fa?page=1&sort=1&ftyp=all&fgrp=all&fyrs=all" target="_blank">NanoCurcumin caused a significant decrease in the levels of LPO compared to the AIP-exposed groups (P < 0. 05). Moreover, in the Curcumin/fa?page=1&sort=1&ftyp=all&fgrp=all&fyrs=all" target="_blank">NanoCurcumintreated groups, compared to a poisoned group, TAC and TTG increased significantly (P < 0. 01). There were no significant changes in CAT activity improvement. Conclusion: Curcumin/fa?page=1&sort=1&ftyp=all&fgrp=all&fyrs=all" target="_blank">NanoCurcumin and Curcumin improved the AIP-induced oxidative damage.

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APA: Copy

Mohammadi Pasand, Somayyeh, RANJBAR, AKRAM, KHEIRIPOUR, NEJAT, GHASEMI, HASSAN, & Rafieemehr, Hassan. (2020). Antioxidative Effects of Nanocurcumin and Curcumin Against Aluminum Phosphide-induced Serum Oxidative Stress. AVICENNA JOURNAL OF MEDICAL BIOCHEMISTRY, 8(2), 53-57. SID. https://sid.ir/paper/702908/en

Vancouver: Copy

Mohammadi Pasand Somayyeh, RANJBAR AKRAM, KHEIRIPOUR NEJAT, GHASEMI HASSAN, Rafieemehr Hassan. Antioxidative Effects of Nanocurcumin and Curcumin Against Aluminum Phosphide-induced Serum Oxidative Stress. AVICENNA JOURNAL OF MEDICAL BIOCHEMISTRY[Internet]. 2020;8(2):53-57. Available from: https://sid.ir/paper/702908/en

IEEE: Copy

Somayyeh Mohammadi Pasand, AKRAM RANJBAR, NEJAT KHEIRIPOUR, HASSAN GHASEMI, and Hassan Rafieemehr, “Antioxidative Effects of Nanocurcumin and Curcumin Against Aluminum Phosphide-induced Serum Oxidative Stress,” AVICENNA JOURNAL OF MEDICAL BIOCHEMISTRY, vol. 8, no. 2, pp. 53–57, 2020, [Online]. Available: https://sid.ir/paper/702908/en

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