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Information Journal Paper

Title

Evaluation of the Effects Due to Injection of Biological Magnetic Iron Nanoparticles in Ovarian Tissue of Female Wistar Rats in Response to Electromagnetic Field

Pages

  63-71

Abstract

 Introduction: The use of different nanoparticles has recently found new dimensions in the treatment of many malignancies. Therefore, this study aimed to investigate the accumulation rate and tissue effects due to injection of biological magnetic iron nanoparticles in the ovarian tissue of Wistar rats in response to an electromagnetic field using inductively coupled plasma (ICP) and histopathological methods. Methods: In this experimental study, animals were classified into four groups of six as follows: 1) group of healthy female rats without receiving nanoparticles in the absence of an electromagnetic field (control group), 2) group of healthy female rats receiving non-toxic dose of nanoparticles in the absence of an electromagnetic field, 3) group of healthy female rats receiving non-toxic dose of nanoparticles in the presence of an electromagnetic field, and 4) group of healthy female rats without receiving nanoparticles in the presence of an electromagnetic field. After grouping the rats, biological nanoparticles were injected intraperitoneally, and an electromagnetic field was created on the rats' skin at the site of the ovaries by a magnet, which was fixed on the skin using a tape. Then the presence of iron nanoparticles in the tissue was examined using ICP. Results: Magnetic iron nanoparticles had low toxicity so that their half-maximal inhibitory concentration (IC50) in well Number 1 was 0. 386. In the two groups receiving non-toxic doses of nanoparticles in the presence or absence of the electromagnetic field, no changes were observed in primary and secondary follicles as well as connective tissue and blood. Conclusion: Magnetic iron nanoparticles have no destructive effects on ovarian tissue and have low cell accumulation; therefore, their use in this field is recommended to improve the future treatment of ovarian cancer.

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    Cite

    APA: Copy

    Nouri, Mahnaz, Yahyaei, Behrooz, & Najafalipour, Fatemeh. (2021). Evaluation of the Effects Due to Injection of Biological Magnetic Iron Nanoparticles in Ovarian Tissue of Female Wistar Rats in Response to Electromagnetic Field. PATHOBIOLOGY RESEARCH (MODARES JOURNAL OF MEDICAL SCIENCES), 24(1 ), 63-71. SID. https://sid.ir/paper/703352/en

    Vancouver: Copy

    Nouri Mahnaz, Yahyaei Behrooz, Najafalipour Fatemeh. Evaluation of the Effects Due to Injection of Biological Magnetic Iron Nanoparticles in Ovarian Tissue of Female Wistar Rats in Response to Electromagnetic Field. PATHOBIOLOGY RESEARCH (MODARES JOURNAL OF MEDICAL SCIENCES)[Internet]. 2021;24(1 ):63-71. Available from: https://sid.ir/paper/703352/en

    IEEE: Copy

    Mahnaz Nouri, Behrooz Yahyaei, and Fatemeh Najafalipour, “Evaluation of the Effects Due to Injection of Biological Magnetic Iron Nanoparticles in Ovarian Tissue of Female Wistar Rats in Response to Electromagnetic Field,” PATHOBIOLOGY RESEARCH (MODARES JOURNAL OF MEDICAL SCIENCES), vol. 24, no. 1 , pp. 63–71, 2021, [Online]. Available: https://sid.ir/paper/703352/en

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