مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

video

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

sound

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Version

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

View:

267
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Download:

210
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Cites:

Information Journal Paper

Title

ANTI-INFLAMMATORY EFFECTS OF CURCUMIN ON INSULIN RESISTANCE INDEX, LEVELS OF INTERLEUKIN-6, C-REACTIVE PROTEIN, AND LIVER HISTOLOGY IN POLYCYSTIC OVARY SYNDROME-INDUCED RATS

Pages

  425-433

Abstract

 Objective: CURCUMIN protects the LIVER against injury and fibrosis through suppressing hepatic inflammation, attenuating hepatic oxidative stress (OS), and inhibiting hepatic stellate cells (HSCs) activation. Non-alcoholic fatty LIVER disease (NAFLD) and polycystic ovary syndrome (PCOS) are considered as common metabolic disorders. Low-grade chronic inflammation with different markers, such as elevated C-reactive protein (CRP) and interleukin-6 (IL-6) levels, play a crucial role in PCOS. This study aimed to evaluate the therapeutic effects of CURCUMIN on IL-6 and CRP levels as well as INSULIN RESISTANCE (IR) index on LIVER function in PCOS rats.Materials and Methods: In this experimental study, 90 adult Wistar rats were divided into control (n=18), sham (n=18), PCOS (n=18) and CURCUMIN-treated PCOS groups (n=36). PCOS group was injected subcutaneously with 2 mg estradio-valerate (E2V). After 60 days, PCOS group was treated with CURCUMIN [100 and 300 mg/kg body weight (BW)] for 14 days and anesthetized by chloroform. Blood and LIVER samples were collected for histological and serological analyses. Data were analyzed using In-Stat 3 via one-way analysis of variance (ANOVA).Results: Histological and serological analyses showed a reduction in number of necrotic cells, IR index, as well as IL-6 and CRP levels in PCOS rats that were treated with various concentrations of CURCUMIN.Conclusion: In this study, CURCUMIN decreased LIVER inflammation by induction of insulin sensitivity and reduction of hepatic necrosis. Therefore, CURCUMIN may be considered as protective factor against inflammatory state of PCOS.

Cites

  • No record.

    • References

    Cite

    APA: Copy

    MOHAMMADI, SHIMA, KARIMZADEH BARDEI, LATIFEH, HOJATI, VIDA, GHORBANI, AZITA, & NABIUNI, MOHAMMAD. (2017). ANTI-INFLAMMATORY EFFECTS OF CURCUMIN ON INSULIN RESISTANCE INDEX, LEVELS OF INTERLEUKIN-6, C-REACTIVE PROTEIN, AND LIVER HISTOLOGY IN POLYCYSTIC OVARY SYNDROME-INDUCED RATS. CELL JOURNAL (YAKHTEH), 19(3), 425-433. SID. https://sid.ir/paper/704037/en

    Vancouver: Copy

    MOHAMMADI SHIMA, KARIMZADEH BARDEI LATIFEH, HOJATI VIDA, GHORBANI AZITA, NABIUNI MOHAMMAD. ANTI-INFLAMMATORY EFFECTS OF CURCUMIN ON INSULIN RESISTANCE INDEX, LEVELS OF INTERLEUKIN-6, C-REACTIVE PROTEIN, AND LIVER HISTOLOGY IN POLYCYSTIC OVARY SYNDROME-INDUCED RATS. CELL JOURNAL (YAKHTEH)[Internet]. 2017;19(3):425-433. Available from: https://sid.ir/paper/704037/en

    IEEE: Copy

    SHIMA MOHAMMADI, LATIFEH KARIMZADEH BARDEI, VIDA HOJATI, AZITA GHORBANI, and MOHAMMAD NABIUNI, “ANTI-INFLAMMATORY EFFECTS OF CURCUMIN ON INSULIN RESISTANCE INDEX, LEVELS OF INTERLEUKIN-6, C-REACTIVE PROTEIN, AND LIVER HISTOLOGY IN POLYCYSTIC OVARY SYNDROME-INDUCED RATS,” CELL JOURNAL (YAKHTEH), vol. 19, no. 3, pp. 425–433, 2017, [Online]. Available: https://sid.ir/paper/704037/en

    Related Journal Papers

  • No record.

    • Related Seminar Papers

  • No record.

    • Related Plans

  • No record.

    • Recommended Workshops






    Move to top
    telegram sharing button
    whatsapp sharing button
    linkedin sharing button
    twitter sharing button
    email sharing button
    email sharing button
    email sharing button
    sharethis sharing button