Correlation between stromal cell-derived factor 1 and the prognosis of transient ischemic attack

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Liu Mingjie; Xie Jing; Zheng Xinxin; Wang Mengmeng; Chen Guanglong; WANG TAO; Lu Yi

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Journal Paper

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Journal: Iranian Red Crescent Medical Journal Year:2021 | Volume:23 | Issue:5 Page(s): 0-0

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Title

Correlation between stromal cell-derived factor 1 and the prognosis of transient ischemic attack

Author(s)

Keywords

Cerebral infarction

Chemokine CXCL12

Transient ischemic attack

Abstract

Background: Transient ischemic attack (TIA) (1) is a neurological dysfunction of transient cerebrovascular ischemia, which is more common in clinical practice. The risk of further progression to ischemic stroke after a higher TIA can be used as a strong early warning signal of Cerebral infarction. Objectives: To explore the correlation between stromal cell-derived factor 1 (SDF-1) and the prognosis of TIA. Methods: A number of 65 patients with TIA were collected, the ABCD2 clinical risk prediction score was implemented, relevant tests and nuclear magnetic resonance imaging (MRI) were performed, and the SDF-1 was recorded in serum levels. End-point events were selected in patients after Cerebral infarction in the short term. The statistical analysis method was used to evaluate TIA short-term development for the occurrence of Cerebral infarction after risk, the severity of serum level of SDF-1, and infarction. Results: Based on the results, the high-risk group, middle-risk group, and low-risk group had statistically significant differences in serum SDF-1 levels (F=3. 820; P<0. 05). Correlation analysis demonstrated that ABCD2 score was positively correlated with serum SDF-1 (r=0. 349; P<0. 05). End-point events were included in the occurrence group and not included in the non-occurrence group. The SDF-1 level of the occurrence group was significantly higher than that of the non-occurrence group. Based on the cranial MRI results as the gold standard, the areas under the curve of the receiver operating characteristic curve (ROC) drawn based on the SDF-1, ABCD2 score, SDF-1 combined with the ABCD2 score, and the occurrence of end-point events were obtained at 0. 717, 0. 697, and 0. 762, respectively. The sensitivity and specificity of SDF-1 were reported as 77. 8% and 68. 1%, respectively. The sensitivity and specificity of the ABCD2 score were 83. 3% and 48. 9%, respectively. The sensitivity and specificity of SDF-1 combined with the ABCD2 score were 72. 2% and 76. 6%, respectively. Conclusion: As evidenced by the obtained results, SDF-1 is associated with ABCD2 score risk classification. Patients with high levels of SDF-1 combined with the ABCD2 score have a higher risk of Cerebral infarction. Elevated SDF-1 levels may indicate that TIA patients have a poor short-term prognosis and have a certain predictive value for the diagnosis of the risk of ischemic stroke in the short term.

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APA: Copy

Liu, Mingjie, Xie, Jing, Wang, Mengmeng, Chen, Guanglong, WANG, TAO, Lu, Yi, & Zheng, Xinxin. (2021). Correlation between stromal cell-derived factor 1 and the prognosis of transient ischemic attack. IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ), 23(5), 0-0. SID. https://sid.ir/paper/704490/en

Vancouver: Copy

Liu Mingjie, Xie Jing, Wang Mengmeng, Chen Guanglong, WANG TAO, Lu Yi, Zheng Xinxin. Correlation between stromal cell-derived factor 1 and the prognosis of transient ischemic attack. IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ)[Internet]. 2021;23(5):0-0. Available from: https://sid.ir/paper/704490/en

IEEE: Copy

Mingjie Liu, Jing Xie, Mengmeng Wang, Guanglong Chen, TAO WANG, Yi Lu, and Xinxin Zheng, “Correlation between stromal cell-derived factor 1 and the prognosis of transient ischemic attack,” IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ), vol. 23, no. 5, pp. 0–0, 2021, [Online]. Available: https://sid.ir/paper/704490/en

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