Comparison of Gold Nanoparticles and Iodinated Contrast Media in Radiation Dose Reduction and Contrast Enhancement in Computed Tomography

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Taghavi Hamid; BAKHSHANDEH MOHSEN; MONTAZERABADI ALIREZA; Nazari Moghadam Hossein; MAZLOUM SHAHRI SEYED BEHNAM; KESHTKAR MOHAMMAd

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Journal: Iranian Journal of Radiology Year:2020 | Volume:17 | Issue:1 Page(s): 0-0

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Title

Comparison of Gold Nanoparticles and Iodinated Contrast Media in Radiation Dose Reduction and Contrast Enhancement in Computed Tomography

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Keywords

Computed Tomography

Gold Nanoparticles

Iodinated Compounds

Image Contrast

Radiation Dose

Abstract

Background: Gold Nanoparticles with high atomic number and density have good potential to be used as contrast media in Computed Tomography. Objectives: In this study, we aimed to assess Radiation Dose and contrast enhancement performance of Gold Nanoparticles by measuring contrast to noise ratio compared to clinically used iodinated contrast agents at same concentrations. Contrast enhancement was evaluated in diﬀ erent tube voltages and currents. Methods: First, polyethylene glycol coated Gold Nanoparticles were synthesized with concentrations of 0. 5 mM, 0. 6 mM, and 0. 7 mM. Gold Nanoparticles and iodinated contrast media were scanned with CT imaging system at diﬀ erent tube voltages and timecurrent product. CT dose index (CTDI) value was measured by special phantom and electrometer. Improving in Image Contrast was assessed by contrast to noise ratio. Results: Results showed that Gold Nanoparticles in all concentrations and energies from 80 to 130 kVp display higher Image Contrastto-noise ratio (CNR) than iodinated contrast media. Image CNR was increased by increasing kVp and mAs. The CNR value was maximum at the voltage of 80 and 130 kVp for Iodinated Compounds and Gold Nanoparticles, respectively. The CNR value for Gold Nanoparticles at 130 kVp and 200 mAs was approximately ﬁ ve times higher than that of Iodinated Compounds. Conclusion: Gold Nanoparticles could be a good candidate for optimizing CT imaging by lowering Radiation Dose as low as possible while enhancing the Image Contrast.

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APA: Copy

Taghavi, Hamid, BAKHSHANDEH, MOHSEN, MONTAZERABADI, ALIREZA, Nazari Moghadam, Hossein, MAZLOUM SHAHRI, SEYED BEHNAM, & KESHTKAR, MOHAMMAd. (2020). Comparison of Gold Nanoparticles and Iodinated Contrast Media in Radiation Dose Reduction and Contrast Enhancement in Computed Tomography. IRANIAN JOURNAL OF RADIOLOGY, 17(1), 0-0. SID. https://sid.ir/paper/705714/en

Vancouver: Copy

Taghavi Hamid, BAKHSHANDEH MOHSEN, MONTAZERABADI ALIREZA, Nazari Moghadam Hossein, MAZLOUM SHAHRI SEYED BEHNAM, KESHTKAR MOHAMMAd. Comparison of Gold Nanoparticles and Iodinated Contrast Media in Radiation Dose Reduction and Contrast Enhancement in Computed Tomography. IRANIAN JOURNAL OF RADIOLOGY[Internet]. 2020;17(1):0-0. Available from: https://sid.ir/paper/705714/en

IEEE: Copy

Hamid Taghavi, MOHSEN BAKHSHANDEH, ALIREZA MONTAZERABADI, Hossein Nazari Moghadam, SEYED BEHNAM MAZLOUM SHAHRI, and MOHAMMAd KESHTKAR, “Comparison of Gold Nanoparticles and Iodinated Contrast Media in Radiation Dose Reduction and Contrast Enhancement in Computed Tomography,” IRANIAN JOURNAL OF RADIOLOGY, vol. 17, no. 1, pp. 0–0, 2020, [Online]. Available: https://sid.ir/paper/705714/en

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