INHIBITORY EFFECTS OF CURCUMIN, LAWSONIA, AND GINGER ON KAOLIN INDUCED PAW EDEMA IN RAT

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KHAKSARI M.; NIKKHOO S.; AMERI A.

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Journal: JOURNAL OF RAFSANJAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES Year:2002 | Volume:1 | Issue:2 Page(s): 99-107

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Title

INHIBITORY EFFECTS OF CURCUMIN, LAWSONIA, AND GINGER ON KAOLIN INDUCED PAW EDEMA IN RAT

Author(s)

KHAKSARI M. | NIKKHOO S. | AMERI A. | Issue Writer Certificate

Keywords

CURCUMINQ1

LAWSONIAQ4

GINGERQ2

PAW EDEMAQ4

ACUTE INFLAMMATIONQ4

Abstract

Background: CURCUMIN is a yellow pigment that is extracted from turmeric. LAWSONIA (2-hydroxy 1,4 naphtoquinon) is a natural product and is extracted from henna. GINGER is a dried rhizome obtained from a plant called zingier officinal a, which is extracted from the GINGER family. In the present study, the anti-inflammatory effects of three chemical agents were evaluated on kaolin induced PAW EDEMA and these effects were compared to ibuprofen. Materials and Methods: This experimental study was performed on adult male rats. Acute inflammatory edema was induced by intraplantar injection of 0.1ml of 4% kaolin. Various concentrations of CURCUMIN 5, 10µmol, LAWSONIA 20, 40µmol, GINGER 5, 20 mg/kg and ibuprofen 12mg/kg were given Subcutaneous. immediately after kaolin injection. PAW EDEMA assessed by calculation of volume changes and by extravasations of Evans blue dye in test group compare to the control, 4 hours after kaolin injection. Results: The results showed that 4% kaolin increased paw volume by 0.36±0.06ml, which was significantly inhibited by CURCUMIN 69.4% at both concentrations (P<0.001). Lawosonia also had significant inhibitory effect on increased paw volume, by 72% and 66% at 20 and 40 µmol respectively (P<0.001). The paw volume was significantly reduced, 38.8%, and 44.8% by GINGER at 5 and 20mg/kg respectively (P<0.01). No significant difference were found between inhibitory effects of ibuprofen and CURCUMIN or LAWSONIA, but the effects of ibuprofen was found to be more than GINGER (P<0.05). Kaolin injection also induced 37% increase in Evans blue extravasations, which was reduced only by GINGER 30.7% and 33.3% at low and high doses respectively. Conclusion: These data suggest that, CURCUMIN, LAWSONIA, and GINGER can inhibit kaolin-induced inflammatory edema, so that the effects of CURCUMIN and LAWSONIA are comparable to ibuprofen. GINGER also reduced protein leakage from vessels.

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APA: Copy

KHAKSARI, M., NIKKHOO, S., & AMERI, A.. (2002). INHIBITORY EFFECTS OF CURCUMIN, LAWSONIA, AND GINGER ON KAOLIN INDUCED PAW EDEMA IN RAT . JOURNAL OF RAFSANJAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES, 1(2), 99-107. SID. https://sid.ir/paper/70733/en

Vancouver: Copy

KHAKSARI M., NIKKHOO S., AMERI A.. INHIBITORY EFFECTS OF CURCUMIN, LAWSONIA, AND GINGER ON KAOLIN INDUCED PAW EDEMA IN RAT . JOURNAL OF RAFSANJAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES[Internet]. 2002;1(2):99-107. Available from: https://sid.ir/paper/70733/en

IEEE: Copy

M. KHAKSARI, S. NIKKHOO, and A. AMERI, “INHIBITORY EFFECTS OF CURCUMIN, LAWSONIA, AND GINGER ON KAOLIN INDUCED PAW EDEMA IN RAT ,” JOURNAL OF RAFSANJAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES, vol. 1, no. 2, pp. 99–107, 2002, [Online]. Available: https://sid.ir/paper/70733/en

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