EFFECT OF DEXAMETHASONE AND SWIMMING STRESS ON PAIN MODULATION BY TWO PAIN ASSESSMENT METHODS IN ALBINO MICE

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TAHERIAN ABAS ALI; VAFAEI A.A.; RASHIDIPOUR A.; MILADI GORJI H.; JARAHI M.

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Journal: JOURNAL OF RAFSANJAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES Year:2003 | Volume:2 | Issue:1 Page(s): 45-51

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Title

EFFECT OF DEXAMETHASONE AND SWIMMING STRESS ON PAIN MODULATION BY TWO PAIN ASSESSMENT METHODS IN ALBINO MICE

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Keywords

GLUCOCORTICOID RECEPTORSQ4

PAINQ2

STRESSQ4

TAIL FLICKQ4

HOT PLATEQ2

ALBINO MICEQ4

Abstract

Background: Previous findings have indicated that glucocorticoids may have an important role in the modulation of acute and chronic pain. The present work investigated the effect of acute STRESS and dexamethasone (as a glucocorticoids, agonist) on acute PAIN by two assessment methods (Hot Plate and TAIL FLICK) in ALBINO MICE. Materials and Methods: In this experiment 60 ALBINO MICE (25-30g) were divided into 6 groups. The animals were given 2 days to adapt to the experiment,s condition.TAIL FLICK and HOT PLATE tests were used for evaluation of analgesic effect of the drug and stress. Dexamethasone( 0.5, 1 and 2 mg/kg) as an agonist of glucocorticoids and saline were injected 3 minutes before the test or before the animals received STRESS by swiming in cold water (18 – 22oc).The sign of PAIN was movement of tail in TAIL FLICK and grooming in hot plate.Results: The findings of this study indicated that the STRESS of cold water and Dexamethasone (0.5 and 1mg/kg) have reduced the animals, responses to PAIN stimulants in both methods significantly (p<0.01). The effect of 2mg/kg Dexamethasone was not significant whereas the effects of STRESS alone were more than Dexamethasone.Conclusion: The present data showed that STRESS and the activation of glucocorticoids, receptors reduce the acute pain. To understand the analgesic mechanisms of STRESS and glucocorticoids, further studies remain to be accomplished.

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APA: Copy

TAHERIAN, ABAS ALI, VAFAEI, A.A., RASHIDIPOUR, A., MILADI GORJI, H., & JARAHI, M.. (2003). EFFECT OF DEXAMETHASONE AND SWIMMING STRESS ON PAIN MODULATION BY TWO PAIN ASSESSMENT METHODS IN ALBINO MICE. JOURNAL OF RAFSANJAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES, 2(1), 45-51. SID. https://sid.ir/paper/70781/en

Vancouver: Copy

TAHERIAN ABAS ALI, VAFAEI A.A., RASHIDIPOUR A., MILADI GORJI H., JARAHI M.. EFFECT OF DEXAMETHASONE AND SWIMMING STRESS ON PAIN MODULATION BY TWO PAIN ASSESSMENT METHODS IN ALBINO MICE. JOURNAL OF RAFSANJAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES[Internet]. 2003;2(1):45-51. Available from: https://sid.ir/paper/70781/en

IEEE: Copy

ABAS ALI TAHERIAN, A.A. VAFAEI, A. RASHIDIPOUR, H. MILADI GORJI, and M. JARAHI, “EFFECT OF DEXAMETHASONE AND SWIMMING STRESS ON PAIN MODULATION BY TWO PAIN ASSESSMENT METHODS IN ALBINO MICE,” JOURNAL OF RAFSANJAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES, vol. 2, no. 1, pp. 45–51, 2003, [Online]. Available: https://sid.ir/paper/70781/en

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