THE ROLE OF GLUCOCORTICOID S SYSTEM IN ACCUMBENS NUCLEUS ON LEARNING AND MEMORY PROCESSES IN RAT

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

VAFAEI A.A.; JALAL A.; RASHIDIPOUR A.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Journal of Rafsanjan University of Medical Sciences Year:2004 | Volume:3 | Issue:1 Page(s): 25-33

Download Full-Text

Persian Verion

View:

872

Download:

Cites:

Information Journal Paper

Title

THE ROLE OF GLUCOCORTICOID S SYSTEM IN ACCUMBENS NUCLEUS ON LEARNING AND MEMORY PROCESSES IN RAT

Author(s)

VAFAEI A.A. | JALAL A. | RASHIDIPOUR A. | Issue Writer Certificate

Keywords

ACCUMBENS NUCLEUSQ3

LEARNING AND MEMORYQ2

CORTICOSTERONEQ2

RU38486Q3

RATQ2

Abstract

Background: Previous study indicated that glucocorticoid’s receptors (GRc) in ACCUMBENS NUCLEUS (AN) probably are involved in modulation the processes of emotional memory storage. The aim of the present work was to determine the effect of agonist and antagonist of GRc on the modulation of memory processes (Acquisition, Consolidation and Retrieval) in AN of RAT in Passive Avoidance Learning (PAL) model.Materials and Methods: This experimental study was carried out on 120 (12 groups) male Albino Wistar RATs (220 – 250 g body weight). Two cannulae implanted bilaterally at the AN and after week the animals were trained in PAL. CORTICOSTERONE (1 µg/µl/side) as an agonist and RU38486 (3ng/µl/side) as an antagonist of GRc were injected bilaterally before, immediately after the training and before the retrieval test. Control RATs received the same volume of Vehicle. Two days later, retention test was done and Step-through Latency to the dark chamber and total time that spend in light chamber in 10 minutes used as two criteria for measurement of memory.Results: Results indicated that bilaterally injection of agonist and antagonist of GRc immediately after training enhanced and impaired the memory consolidation respectively (P<0.01). But injection these drugs before the training and before the retrieval test had not significant effects on emotional memory processes.Conclusion: Findings of this experiment showed that glucocorticoid’s receptors in AN have important role in memory consolidation of new emotional data in PAL.

Cites

No record.

References

Cite

APA: Copy

VAFAEI, A.A., JALAL, A., & RASHIDIPOUR, A.. (2004). THE ROLE OF GLUCOCORTICOID S SYSTEM IN ACCUMBENS NUCLEUS ON LEARNING AND MEMORY PROCESSES IN RAT. JOURNAL OF RAFSANJAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES, 3(1), 25-33. SID. https://sid.ir/paper/70849/en

Vancouver: Copy

VAFAEI A.A., JALAL A., RASHIDIPOUR A.. THE ROLE OF GLUCOCORTICOID S SYSTEM IN ACCUMBENS NUCLEUS ON LEARNING AND MEMORY PROCESSES IN RAT. JOURNAL OF RAFSANJAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES[Internet]. 2004;3(1):25-33. Available from: https://sid.ir/paper/70849/en

IEEE: Copy

A.A. VAFAEI, A. JALAL, and A. RASHIDIPOUR, “THE ROLE OF GLUCOCORTICOID S SYSTEM IN ACCUMBENS NUCLEUS ON LEARNING AND MEMORY PROCESSES IN RAT,” JOURNAL OF RAFSANJAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES, vol. 3, no. 1, pp. 25–33, 2004, [Online]. Available: https://sid.ir/paper/70849/en

Related Journal Papers