مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Information Journal Paper

Title

LONG-TERM ADMINISTRATION OF OLANZAPINE INDUCES ADIPOSITY AND INCREASES HEPATIC FATTY ACID DESATURATION PROTEIN IN FEMALE C57BL/6J MICE

Pages

  495-501

Keywords

STEAROYL-COA DESATURASE-1- (SCD-1) 

Abstract

 Objective (s): Weight gain and metabolic disturbances such as dyslipidemia, are frequent side effects of second-generation antipsychotics, including OLANZAPINE. This study examined the metabolic effects of chronic OLANZAPINE exposure. In addition, we investigated the hepatic fatty acid effects of OLANZAPINE in female C57BL/6J mice fed a normal diet.Materials and Methods: Female C57BL/6J mice orally received OLANZAPINE or normal saline for 7 weeks. The effects of long-term OLANZAPINE exposure on body weight changes, food efficiency, blood glucose, TRIGLYCERIDE (TG), INSULIN, and leptin levels were observed. Hepatic TG and abdominal fat mass were investigated, and fat cell morphology was analyzed through histopathological methods. The levels of protein markers of fatty acid regulation in the liver, namely fatty acid synthase (FAS) and stearoyl-CoA desaturase-1 (SCD-1), were measured.Results: OLANZAPINE treatment increased the food intake of the mice as well as their body weight. Biochemical analyses showed that OLANZAPINE increased blood TG, INSULIN, leptin, and hepatic TG. The OLANZAPINE group exhibited increased abdominal fat mass and fat cell enlargement in abdominal fat tissue. Western blotting of the mouse liver revealed significantly higher (1.6-fold) levels of SCD-1 in the OLANZAPINE group relative to the control group; by contrast, FAS levels in the two groups did not differ significantly.Conclusion: Enhanced lipogenesis triggered by increased hepatic SCD-1 activity might be a probable peripheral mechanism of OLANZAPINE-induced dyslipidemia. Some adverse metabolic effects of OLANZAPINE may be related to the disturbance of lipid homeostasis in the liver.

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    • Cite

    APA: Copy

    HOU, PO HSUN, CHANG, GENG RUEI, CHEN, CHIN PIN, CHAO, I SHUAN, SHEN, TING TING, & MAO, FRANK CHIAHUNG. (2018). LONG-TERM ADMINISTRATION OF OLANZAPINE INDUCES ADIPOSITY AND INCREASES HEPATIC FATTY ACID DESATURATION PROTEIN IN FEMALE C57BL/6J MICE. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 21(5), 495-501. SID. https://sid.ir/paper/708889/en

    Vancouver: Copy

    HOU PO HSUN, CHANG GENG RUEI, CHEN CHIN PIN, CHAO I SHUAN, SHEN TING TING, MAO FRANK CHIAHUNG. LONG-TERM ADMINISTRATION OF OLANZAPINE INDUCES ADIPOSITY AND INCREASES HEPATIC FATTY ACID DESATURATION PROTEIN IN FEMALE C57BL/6J MICE. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2018;21(5):495-501. Available from: https://sid.ir/paper/708889/en

    IEEE: Copy

    PO HSUN HOU, GENG RUEI CHANG, CHIN PIN CHEN, I SHUAN CHAO, TING TING SHEN, and FRANK CHIAHUNG MAO, “LONG-TERM ADMINISTRATION OF OLANZAPINE INDUCES ADIPOSITY AND INCREASES HEPATIC FATTY ACID DESATURATION PROTEIN IN FEMALE C57BL/6J MICE,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 21, no. 5, pp. 495–501, 2018, [Online]. Available: https://sid.ir/paper/708889/en

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